Biologic Therapies for Severe Asthma

被引：318
|
作者：
Brusselle, Guy G. [1 ,2 ]
Koppelman, Gerard H. [3 ,4 ]
机构：
[1] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium
[2] Erasmus MC, Dept Epidemiol & Resp Med, Rotterdam, Netherlands
[3] Univ Groningen, Dept Pediat Pulmonol & Pediat Allergol, Beatrix Childrens Hosp, Univ Med Ctr Groningen, Groningen, Netherlands
[4] Univ Groningen, Groningen Res Inst Asthma & COPD, Univ Med Ctr Groningen, Groningen, Netherlands
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 386卷 / 02期
关键词：
SEVERE EOSINOPHILIC ASTHMA; QUALITY-OF-LIFE; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; PRECISION MEDICINE; NASAL POLYPOSIS; MEPOLIZUMAB; PLACEBO; BENRALIZUMAB; EFFICACY;
D O I：
10.1056/NEJMra2032506
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may be required to reduce the disease burden. This review discusses the mechanisms, efficacy, and safety of biologics for severe asthma.
引用
收藏
页码：157 / 171
页数：15
相关论文
共 50 条
  • [21] Biologic therapies for asthma in underserved populations
    Kelly, Rachel S.
    Weiss, Scott T.
    [J]. LANCET, 2022, 400 (10351): : 471 - 473
  • [22] Navigating biologic therapies in elderly asthma
    Ji, Hyein
    Tan, Laren D.
    Hafzalla, George W.
    Nguyen, Nolan
    Alismail, Abdullah
    [J]. RESPIRATORY MEDICINE, 2024, 227
  • [23] EFFICACY OF BIOLOGIC THERAPIES IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA STRATIFIED BY BLOOD EOSINOPHIL COUNT
    Busse, W.
    FitzGerald, M.
    Korn, S.
    Cook, B.
    Llanos-Ackert, J.
    Ambrose, C.
    [J]. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2021, 127 (05) : S34 - S34
  • [24] Differences in the Preferences of Allergists and Pulmonologists for their Ideal Administration Route of Severe Asthma Biologic Therapies
    Kyle, A.
    Hanarz, K.
    Brown, S.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [25] Effect of biologic therapies on quality of life in severe asthma Findings from the PRISM study
    Rhyou, Hyo-In
    Kim, Hyun-Kyoung
    Song, Woo-Jung
    Lee, Sang Min
    Kim, Sang-Ha
    Kwon, Jae-Woo
    Park, Han-Ki
    Park, Hye-Kyung
    Kim, Sang Hoon
    Choi, Jeong-Hee
    Kim, Sujeong
    Park, So-Young
    Kim, Sae-Hoon
    Moon, Ji-Yong
    Jung, Jae-Woo
    Cho, Young-Joo
    Park, Chan Sun
    Kim, Byung Keun
    Kim, Joo-Hee
    Yang, Min-Suk
    Kim, Min-Hye
    Nam, Young-Hee
    Lee, Taehoon
    Lee, Byung-Jae
    Bhavsar, Pankaj
    Adcock, Ian M.
    Chung, Kian Fan
    Kim, Tae-Bum
    [J]. WORLD ALLERGY ORGANIZATION JOURNAL, 2024, 17 (09):
  • [26] Clinical and economic burden of severe asthma among US patients treated with biologic therapies
    Reibman, Joan
    Tan, Laren
    Ambrose, Chris
    Chung, Yen
    Desai, Pooja
    Llanos, Jean-Pierre
    Moynihan, Meghan
    Tkacz, Joseph
    [J]. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2021, 127 (03) : 318 - +
  • [27] Exploring Perceptions of Biologic Therapies: A Qualitative Study Among Canadians Living with Severe Asthma
    Bever, Andrea
    Dunne, Jessica
    Reynolds, Jenna
    Waserman, Susan
    Kaplan, Alan G.
    O'Keefe, Andrew
    McNeilly, Stacey
    Szabo, Shelagh M.
    [J]. ADVANCES IN THERAPY, 2024, 41 (04) : 1401 - 1418
  • [28] Exploring Perceptions of Biologic Therapies: A Qualitative Study Among Canadians Living with Severe Asthma
    Andrea Bever
    Jessica Dunne
    Jenna Reynolds
    Susan Waserman
    Alan G. Kaplan
    Andrew O’Keefe
    Stacey McNeilly
    Shelagh M. Szabo
    [J]. Advances in Therapy, 2024, 41 : 1401 - 1418
  • [29] The use of biologic therapies for the management of pediatric asthma
    Lovinsky-Desir, Stephanie
    [J]. PEDIATRIC PULMONOLOGY, 2020, 55 (03) : 803 - 808
  • [30] Current and Emerging Biologic Therapies for Asthma and COPD
    Wechsler, Michael E.
    [J]. RESPIRATORY CARE, 2018, 63 (06) : 699 - 707
12345