Vitamin D, Immunoregulation, and Rheumatoid Arthritis

被引：43
|
作者：
Wen, Hongyan [1 ,2 ,3 ]
Baker, Joshua F. [2 ]
机构：
[1] Shanxi Med Univ, Hosp 2, Taiyuan 030001, Shanxi Province, Peoples R China
[2] Univ Penn, Dept Med, Div Rheumatol, Philadelphia, PA 19104 USA
[3] VA Med Ctr, Philadelphia, PA USA
来源：
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY | 2011年 / 17卷 / 02期
关键词：
vitamin D; immunoregulation; rheumatoid arthritis; DENDRITIC CELL-DIFFERENTIATION; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; T-CELLS; 1,25-DIHYDROXYVITAMIN D-3; DISEASE-ACTIVITY; IMMUNOGLOBULIN PRODUCTION; D METABOLITES; TH17; CELLS; EXPRESSION; INHIBITION;
D O I：
10.1097/RHU.0b013e31820edd18
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In addition to being important in calcium and phosphorus metabolism, bone formation, and mineralization, vitamin D also plays a part in the maintenance of immune homeostasis. Vitamin D receptors are expressed in a number of different tissues, including, and perhaps most notably, on immune cells. The presence or absence of activated vitamin D has a number of effects on in vitro immune cell function. This review describes the possible immunoregulatory role of vitamin D in rheumatoid arthritis with clinical and animal studies.
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收藏
页码：102 / 107
页数：6
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