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Vitamin D, Immunoregulation, and Rheumatoid Arthritis
被引:43
|作者:
Wen, Hongyan
[1
,2
,3
]
Baker, Joshua F.
[2
]
机构:
[1] Shanxi Med Univ, Hosp 2, Taiyuan 030001, Shanxi Province, Peoples R China
[2] Univ Penn, Dept Med, Div Rheumatol, Philadelphia, PA 19104 USA
[3] VA Med Ctr, Philadelphia, PA USA
关键词:
vitamin D;
immunoregulation;
rheumatoid arthritis;
DENDRITIC CELL-DIFFERENTIATION;
1-ALPHA;
25-DIHYDROXYVITAMIN D-3;
T-CELLS;
1,25-DIHYDROXYVITAMIN D-3;
DISEASE-ACTIVITY;
IMMUNOGLOBULIN PRODUCTION;
D METABOLITES;
TH17;
CELLS;
EXPRESSION;
INHIBITION;
D O I:
10.1097/RHU.0b013e31820edd18
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
In addition to being important in calcium and phosphorus metabolism, bone formation, and mineralization, vitamin D also plays a part in the maintenance of immune homeostasis. Vitamin D receptors are expressed in a number of different tissues, including, and perhaps most notably, on immune cells. The presence or absence of activated vitamin D has a number of effects on in vitro immune cell function. This review describes the possible immunoregulatory role of vitamin D in rheumatoid arthritis with clinical and animal studies.
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页码:102 / 107
页数:6
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