Organocatalyst-mediated enantioselective intramolecular Michael addition of aldehydes to vinyl sulfones

被引：18
|
作者：
Bournaud, Chloee [1 ]
Marchal, Estelle [1 ]
Quintard, Adrien [1 ]
Sulzer-Mosse, Sarah [1 ]
Alexakis, Alexandre [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland
来源：
TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 13-14期
关键词：
CONJUGATE ADDITION; DIASTEREOSELECTIVE SYNTHESIS; KETONES; ACIDS; ETHERS;
D O I：
10.1016/j.tetasy.2010.03.043
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Chiral amines with a hydrogen bond donor promote the intramolecular conjugate addition of aldehydes to vinyl sulfones. Chiral cyclic sulfone-aldehydes are obtained in good yields with an ee of up to 82%. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1666 / 1673
页数：8
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