Evidence for Participation of Aluminum in Neurofibrillary Tangle Formation and Growth in Alzheimer's Disease

被引：64

作者：

Walton, J. R. ^{[1
]}

机构：

[1] Univ New S Wales, St George Hosp, Sch Clin, Res & Educ Ctr,Fac Med, Sydney, NSW 2217, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷 / 01期

基金：

英国医学研究理事会;

关键词：

Aluminum; Alzheimer's disease; hyperphosphorylated tau; neurofibrillary tangles; PAIRED HELICAL FILAMENTS; ABNORMALLY PHOSPHORYLATED-TAU; PROTEIN PHOSPHATASE 2A; INDUCED APOPTOSIS; HYPERPHOSPHORYLATED-TAU; CEREBRAL-CORTEX; PHF-TAU; BRAIN; ACCUMULATION; DEGENERATION;

D O I：

10.3233/JAD-2010-100486

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examines hippocampal CA1 cells from brains of aged humans, with and without Alzheimer's disease, for hyperphosphorylated tau and aluminum during early neurofibrillary tangle (NFT) formation and growth. A very small proportion of hippocampal pyramidal cells contain cytoplasmic pools within their soma that either appear homogeneous or contain short filaments (i.e., early NFTs). The cytoplasmic pools are aggregates of an aluminum/hyperphosphorylated tau complex similar to that found in mature NFTs. The photographic evidence presented combines with existing evidence to support a role for aluminum in the formation and growth of NFTs in neurons of humans with Alzheimer's disease.

引用

页码：65 / 72

页数：8

共 50 条

[11] Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders
Mold, Matthew John
O'Farrell, Adam
Morris, Benjamin
Exley, Christopher
JOURNAL OF ALZHEIMERS DISEASE, 2020, 78 (01) : 139 - 149
[12] Senile dementia of the neurofibrillary tangle type: A comparison with Alzheimer's disease
Yamada, M
Itoh, Y
Sodeyama, N
Suematsu, N
Otomo, E
Matsushita, M
Mizusawa, H
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2001, 12 (02) : 117 - 126
[13] Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease
Guillozet-Bongaarts, AL
Garcia-Sierra, F
Reynolds, MR
Horowitz, PM
Fu, YF
Wang, TY
Cahill, ME
Bigio, EH
Berry, RW
Binder, LI
NEUROBIOLOGY OF AGING, 2005, 26 (07) : 1015 - 1022
[14] Neurofibrillary tangle-associated alteration of stathmin in Alzheimer's disease
Jin, LW
Masliah, E
Iimoto, D
Deteresa, R
Mallory, M
Sundsmo, M
Mori, N
Sobel, A
Saitoh, T
NEUROBIOLOGY OF AGING, 1996, 17 (03) : 331 - 341
[15] Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease
Otero-Garcia, Marcos
Mahajani, Sameehan U.
Wakhloo, Debia
Tang, Weijing
Xue, Yue-Qiang
Morabito, Samuel
Pan, Jie
Oberhauser, Jane
Madira, Angela E.
Shakouri, Tamara
Deng, Yongning
Allison, Thomas
He, Zihuai
Lowry, William E.
Kawaguchi, Riki
Swarup, Vivek
Cobos, Inma
NEURON, 2022, 110 (18) : 2929 - +
[16] Progressive neuronal DNA damage associated with neurofibrillary tangle formation in Alzheimer disease
Sheng, JG
Mrak, RE
Griffin, WST
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (04): : 323 - 328
[17] Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
Bussière, T
Gold, G
Kövari, E
Giannakopoulos, P
Bouras, C
Perl, DP
Morrison, JH
Hof, PR
NEUROSCIENCE, 2003, 117 (03) : 577 - 592
[18] Subicular dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle density
Falke, E
Nissanov, J
Mitchell, TW
Bennett, DA
Trojanowski, JQ
Arnold, SE
AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (04): : 1615 - 1621
[19] Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation
Baum, L
Hansen, L
Masliah, E
Saitoh, T
MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1996, 29 (2-3) : 253 - 261
[20] Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation
Kuusisto, E
Salminen, A
Alafuzoff, I
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2002, 28 (03) : 228 - 237

← 1 2 3 4 5 →