Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

被引：136
|
作者：
Dev, Kumlesh K. [1 ,2 ]
Mullershausen, Florian [3 ]
Mattes, Henri [2 ]
Kuhn, Rainer R. [2 ]
Bilbe, Graeme [2 ]
Hoyer, Daniel [2 ]
Mir, Anis [2 ]
机构：
[1] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland
[2] Nova Pharmaceut, Novartis Inst BioMed Res, Dept Neurosci, Basel, Switzerland
[3] Nova Pharmaceut, Novartis Inst BioMed Res, Dept G Prot Coupled Receptors, Basel, Switzerland
来源：
PHARMACOLOGY & THERAPEUTICS | 2008年 / 117卷 / 01期
关键词：
sphingosine-1-phosphate; SIP receptor; FTY720 (fingolimod); central nervous system; multiple sclerosis;
D O I：
10.1016/j.pharmthera.2007.08.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Multiple sclerosis (MS) is an autoimmune, neurological disability with unknown etiology. The current therapies available for MS work by all immunomodulatory action, preventing T-cell- and macrophage-mediated destruction of brain-resident oligodendrocytes and axonal loss. Recently, FTY720 (fingolimod) was shown to significantly reduce relapse rates in MS patients and is currently in Phase III clinical trials. This drug attenuates trafficking of harmful T cells entering the brain by regulating sphingosine-1-phosphate (SIP) receptors. Here, we outline the direct roles that S I P receptors play in the central nervous system (CNS) and discuss additional modalities by which FTY720 may provide direct neuroprotection in MS. (c) 2007 Elsevier Inc. All rights reserved.
引用
下载
收藏
页码：77 / 93
页数：17
相关论文
共 50 条
  • [21] Roles of S1P-receptors in the brain: Implications for FTY720 in multiple sclerosis
    Schubart, A. S.
    Cortes-Cros, M.
    Muellershausen, F.
    Osinde, M.
    Craveiro, L.
    Thallmair, M.
    Schwab, M.
    Sivasankaran, R.
    Wishart, W. L.
    Mir, A.
    Dev, K. K.
    JOURNAL OF NEUROIMMUNOLOGY, 2006, 178 : 161 - 161
  • [22] The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in Apolipoprotein E-deficient mice
    Keul, P.
    Toelle, M.
    Lucke, S.
    Lipinski, K. Von Wnuck
    Heusch, G.
    Schuchardt, M.
    Van der Giet, M.
    Levkau, B.
    EUROPEAN HEART JOURNAL, 2007, 28 : 796 - 797
  • [23] Sphingosine-1-Phosphate Receptor Agonist, FTY720, Restores Coronary Flow Reserve in Diabetic Rats
    Xu, Hongzeng
    Jin, Yuanzhe
    Ni, Haifeng
    Hu, Shengda
    Zhang, Qin
    CIRCULATION JOURNAL, 2014, 78 (12) : 2979 - 2986
  • [24] The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice
    Keul, Petra
    Toelle, Markus
    Lucke, Susann
    Lipinski, Karin von Wnuck
    Heusch, Gerd
    Schuchardt, Mirjam
    van der Giet, Markus
    Levkau, Bodo
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (03) : 607 - 613
  • [25] The Sphingosine-1-Phosphate Receptor Modulator, FTY720, Reverses Diastolic Dysfunction and Hypertrophy in Hypertrophic Cardiomyopathy
    Ryba, David M.
    Warren, Chad M.
    Karam, Chehade N.
    Dovis, Robert T., III
    Chowdhury, Shamim A. K.
    Alvarez, Manuel G.
    Wieczorek, David F.
    Solaro, R. John
    Wolska, Beata M.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2017, 112 : 156 - 157
  • [26] FTY720, a Sphingosine-1-phosphate Signaling Modulater, as a Novel Therapy for Colon Cancer Peritoneal Carcinomatosis
    Aoyagi, T.
    Yamada, A.
    Nagahashi, M.
    Huang, W.
    Terracina, K. P.
    Avini, D.
    Milstien, S.
    Spiegel, S.
    Takabe, K.
    ANNALS OF SURGICAL ONCOLOGY, 2014, 21 : S84 - S85
  • [27] The Sphingosine-1-Phosphate Analog, FTY720, Reverses Diastolic Dysfunction and Hypertrophy in Familial Hypertrophic Cardiomyopathy
    Ryba, David M.
    Warren, Chad M.
    Karam, Chehade N.
    Davis, Robert T., III
    Chowdhury, Shamim A. K.
    Alvarez, Manuel G.
    Wieczorek, David F.
    Solaro, R. John
    Wolska, Beata M.
    FASEB JOURNAL, 2017, 31
  • [28] The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein e-deficient mice
    Keul, Petra
    Toelle, Markus
    Lucke, Susann
    von Wnuck Lipinski, Karin
    Heusch, Gerd
    Schuchardt, Mirjam
    van der Giet, Markus
    Levkau, Bodo
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 42 : S224 - S224
  • [29] Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate
    Chiba, K
    Hoshino, Y
    Ohtsuki, M
    Kataoka, H
    Maeda, Y
    Matsuyuki, H
    Sugahara, K
    Kiuchi, M
    Hirose, R
    Adachi, K
    TRANSPLANTATION PROCEEDINGS, 2005, 37 (01) : 102 - 106
  • [30] Suppression of Hepatocellular Carcinoma Recurrence After Rat Liver Transplantation by FTY720, a Sphingosine-1-Phosphate Analog
    Ushitora, Yuichiro
    Tashiro, Hirotaka
    Ogawa, Takayuki
    Tanimoto, Yoshisato
    Kuroda, Shintaro
    Kobayashi, Tsuyoshi
    Miyata, Yoshihiro
    Itamoto, Toshiyuki
    Asahara, Toshimasa
    Ohdan, Hideki
    TRANSPLANTATION, 2009, 88 (08) : 980 - 986
12345