Effects of central endothelin-1 in normotensive and spontaneously hypertensive rats

被引：1

作者：

Ponomareva, TI ^{[1
]}

Khokhlova, ON ^{[1
]}

Tukhovskaya, EA ^{[1
]}

Murashov, AM ^{[1
]}

机构：

[1] Russian Acad Sci, Pushchino Branch, Lab Biol Tests, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Pushchino 142292, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 03期

关键词：

endothelin-1; rostroventrolateral medulla oblongata; sympathetic activity; ETB-receptors; ETA-receptors; spontaneously hypertensive rats;

D O I：

10.1023/A:1024172611834

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in blood pressure and sympathetic nerve activity induced by local injection of endothelin-1 into the rostroventrolateral medulla were studied in narcotized stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats. Endothelin-1 produced similar biphasic response in both rat strains: a transient increase in blood pressure and sympathetic nerve activity followed by progressive hypotension and bradycardia. Pretreatment with ETB-receptor antagonist BQ788 inhibited sympathetic activation induced by endothelin-1, while pretreatment with the ETA-receptor antagonist N-acetyl-[D-Trp(16)]-endothelin-1 abolished the subsequent hypotension. The antihypotensive effect of ETA-receptor blockade was most effective in normotensive rats. Our findings suggest that cardiovascular disorders in SHRSP rats can be related to peculiarities in the rostroventrolateral medullar endothelin system.

引用

页码：237 / 240

页数：4

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