Immune checkpoint inhibitor sensitivity of DNA repair deficient tumors

被引：0

作者：

Rochefort, Pauline ^{[1
]}

Desseigne, Francoise ^{[1
]}

Bonadona, Valerie ^{[2
]}

Dussart, Sophie ^{[2
]}

Coutzac, Clelia ^{[1
]}

Sarabi, Matthieu ^{[1
]}

de la Fouchardiere, Christelle ^{[1
]}

机构：

[1] Ctr Leon Berard, Dept Med Oncol, F-69008 Lyon, France

[2] Ctr Leon Berard, Unit Genet Epidemiol & Prevent, F-69008 Lyon, France

来源：

IMMUNOTHERAPY | 2021年 / 13卷 / 14期

关键词：

biomarker; BRCA; cancer; DNA repair deficiency; immune checkpoint inhibitors; immunotherapy; microsatellite instability; PROOFREADING DOMAIN MUTATIONS; POLYMERASE-EPSILON; COLORECTAL-CANCER; PD-1; BLOCKADE; MICROSATELLITE INSTABILITY; ANTITUMOR-ACTIVITY; CLINICAL BENEFIT; DAMAGE RESPONSE; OVARIAN-CANCER; OPEN-LABEL;

D O I：

10.2217/imt-2021-0024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Faithful DNA replication is necessary to maintain genome stability and implicates a complex network with several pathways depending on DNA damage type: homologous repair, nonhomologous end joining, base-excision repair, nucleotide-excision repair and mismatch repair. Alteration in components of DNA repair machinery led to DNA damage accumulation and potentially carcinogenesis. Preclinical data suggest sensitivity to immune checkpoint inhibitors in tumors with DNA repair deficiency. Here, we review clinical studies that explored the use of immune checkpoint inhibitor in patient harboring tumor with DNA repair deficiency.

引用

页码：1205 / 1214

页数：10

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