Efficient C2 functionalisation of 2H-2-imidazolines

被引：28

作者：

Bon, Robin S. ^{[1
]}

Sprenkels, Nanda E. ^{[1
]}

Koningstein, Manoe M. ^{[1
]}

Schmitz, Rob F. ^{[1
]}

de Kanter, Frans J. J. ^{[1
]}

Doemling, Alexander ^{[2
]}

Groen, Marinus B. ^{[1
]}

Orru, Romano V. A. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Chem, NL-1081 HV Amsterdam, Netherlands

[2] Univ Pittsburgh, Pittsburgh, PA 15261 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 01期

关键词：

D O I：

10.1039/b713065a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

引用

页码：130 / 137

页数：8

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