The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

被引：22

作者：

Christ, Maximilian G. ^{[1
]}

Clement, Albrecht M. ^{[1
]}

Behl, Christian ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Pathobiochem, Duesbergweg 6, D-55128 Mainz, Germany

来源：

TRENDS IN NEUROSCIENCES | 2020年 / 43卷 / 02期

关键词：

MUTATION;

D O I：

10.1016/j.tins.2019.12.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.

引用

页码：79 / 81

页数：4

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