The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

被引：22
|
作者：
Christ, Maximilian G. [1 ]
Clement, Albrecht M. [1 ]
Behl, Christian [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Pathobiochem, Duesbergweg 6, D-55128 Mainz, Germany
来源：
TRENDS IN NEUROSCIENCES | 2020年 / 43卷 / 02期
关键词：
MUTATION;
D O I：
10.1016/j.tins.2019.12.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.
引用
收藏
页码：79 / 81
页数：4
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