Targeting p21 activated kinase 1 (Pak1) to PAKup Pancreatic Cancer

被引:7
|
作者
Jagadeeshan, Sankar [1 ,2 ]
Venkatraman, Ganesh [3 ]
Rayala, Suresh K. [1 ]
机构
[1] IIT Madras, Dept Biotechnol, Madras, Tamil Nadu, India
[2] Univ Madras, Dept Genet, Madras, Tamil Nadu, India
[3] Sri Ramachandra Univ, Dept Human Genet, Madras, Tamil Nadu, India
关键词
Pak1; pancreatic adenocarcinoma; gemcitabine resistance; inhibitors; SMALL-MOLECULE INHIBITOR; PATHWAYS; KINASES; FRAX597;
D O I
10.1080/14728222.2016.1239719
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1283 / 1285
页数:3
相关论文
共 50 条
  • [31] Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder
    Harms, Frederike L.
    Kloth, Katja
    Bley, Annette
    Denecke, Jonas
    Santer, Rene
    Lessel, Davor
    Hempel, Maja
    Kutsche, Kerstin
    AMERICAN JOURNAL OF HUMAN GENETICS, 2018, 103 (04) : 579 - 591
  • [32] Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells
    Daniels, RH
    Hall, PS
    Bokoch, GM
    EMBO JOURNAL, 1998, 17 (03): : 754 - 764
  • [33] P21-activated kinase, PAK1 and PAK2, induce endothelial cell retraction.
    Zeng, Q
    Lagunoff, D
    Masaracchia, R
    Cote, GP
    Wysolmerski, RB
    MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 32A - 32A
  • [34] Targeting PAK1
    Semenova, Galina
    Chernoff, Jonathan
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2017, 45 : 79 - 88
  • [35] Targeting PAK1 in pancreatic cancer stellate cells increases survival
    Yeo, D.
    He, H.
    Baldwin, G. S.
    Nikfarjam, M.
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2015, 30 : 86 - 86
  • [36] P21 activated kinase-1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection
    Chang, Hao
    He, Kai-Yue
    Li, Chen
    Ni, Yang-Yue
    Li, Mai-Ning
    Chen, Lin
    Hou, Min
    Zhou, Zikai
    Xu, Zhi-Peng
    Ji, Min-Jun
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (24) : 14325 - 14338
  • [37] P21-Activated Kinase (Pak1) is a Negative Regulator of ROS Generation in Ventricular Myocytes
    DeSantiago, Jaime
    Bare, Dan
    Ke, Yunbo
    Solaro, R. John
    Banach, Kathrin
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 614A - 614A
  • [38] The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus
    Bisson, Nicolas
    Wedlich, Doris
    Moss, Tom
    CELL CYCLE, 2012, 11 (07) : 1316 - 1324
  • [39] Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
    Sells, MA
    Knaus, UG
    Bagrodia, S
    Ambrose, DM
    Bokoch, GM
    Chernoff, J
    CURRENT BIOLOGY, 1997, 7 (03) : 202 - 210
  • [40] FYCO1 regulates autophagy and senescence via PAK1/p21 in cataract
    Chen, Shuying
    Zhao, Wei
    Chen, Rongrong
    Sheng, Feiyin
    Gu, Yuzhou
    Hao, Shengjie
    Wu, Di
    Lu, Bing
    Chen, Lu
    Wu, Yuhao
    Xu, Yili
    Han, Yu
    Zhou, Lei
    Riazuddin, S. Amer
    Fu, Qiuli
    Yao, Ke
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2024, 761