Targeting p21 activated kinase 1 (Pak1) to PAKup Pancreatic Cancer

被引:7
|
作者
Jagadeeshan, Sankar [1 ,2 ]
Venkatraman, Ganesh [3 ]
Rayala, Suresh K. [1 ]
机构
[1] IIT Madras, Dept Biotechnol, Madras, Tamil Nadu, India
[2] Univ Madras, Dept Genet, Madras, Tamil Nadu, India
[3] Sri Ramachandra Univ, Dept Human Genet, Madras, Tamil Nadu, India
关键词
Pak1; pancreatic adenocarcinoma; gemcitabine resistance; inhibitors; SMALL-MOLECULE INHIBITOR; PATHWAYS; KINASES; FRAX597;
D O I
10.1080/14728222.2016.1239719
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1283 / 1285
页数:3
相关论文
共 50 条
  • [1] Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
    Muraleedharan Parvathy
    Sreeharshan Sreeja
    Rakesh Kumar
    Madhavan Radhakrishna Pillai
    BMC Cancer, 16
  • [2] Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
    Parvathy, Muraleedharan
    Sreeja, Sreeharshan
    Kumar, Rakesh
    Pillai, Madhavan Radhakrishna
    BMC CANCER, 2016, 16
  • [3] P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer
    Jagadeeshan, S.
    Subramanian, A.
    Tentu, S.
    Beesetti, S.
    Singhal, M.
    Raghavan, S.
    Surabhi, R. P.
    Mavuluri, J.
    Bhoopalan, H.
    Biswal, J.
    Pitani, R. S.
    Chidambaram, S.
    Sundaram, S.
    Malathi, R.
    Jeyaraman, J.
    Nair, A. S.
    Venkatraman, G.
    Rayala, S. K.
    ANNALS OF ONCOLOGY, 2016, 27 (08) : 1546 - 1556
  • [4] Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers
    Kanumuri, Rahul
    Saravanan, Roshni
    Pavithra, V.
    Sundaram, Sandhya
    Rayala, Suresh K.
    Venkatraman, Ganesh
    GENE, 2020, 760
  • [5] Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells
    Ong, Christy C.
    Jubb, Adrian M.
    Haverty, Peter M.
    Zhou, Wei
    Tran, Victoria
    Truong, Tom
    Turley, Helen
    O'Brien, Tom
    Vucic, Domagoj
    Harris, Adrian L.
    Belvin, Marcia
    Friedman, Lori S.
    Blackwood, Elizabeth M.
    Koeppen, Hartmut
    Hoeflich, Klaus P.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (17) : 7177 - 7182
  • [6] ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration
    Yuan, Liangping
    Santi, Mariarita
    Rushing, Elisabeth J.
    Cornelison, Robert
    MacDonald, Tobey J.
    CLINICAL & EXPERIMENTAL METASTASIS, 2010, 27 (07) : 481 - 491
  • [7] ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration
    Liangping Yuan
    Mariarita Santi
    Elisabeth J. Rushing
    Robert Cornelison
    Tobey J. MacDonald
    Clinical & Experimental Metastasis, 2010, 27 : 481 - 491
  • [8] Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells
    Hoeflich, K.
    Ong, C.
    Jubb, A.
    Haverty, P.
    Truong, T.
    Harris, A.
    Belvin, M.
    Friedman, L.
    Blackwood, E.
    Koeppen, H.
    EJC SUPPLEMENTS, 2010, 8 (07): : 109 - 109
  • [9] Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma
    Iyer, Soumya C.
    Gopal, Ashidha
    Halagowder, Devaraj
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2015, 407 (1-2) : 223 - 237
  • [10] p21-activated kinase 1 (PAK1) as a therapeutic target for cardiotoxicity
    Guo, Ping
    Liu, Yufeng
    Feng, Jingrong
    Tang, Shihang
    Wei, Fanyan
    Feng, Jian
    ARCHIVES OF TOXICOLOGY, 2022, 96 (12) : 3143 - 3162