Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists

被引：17
|
作者：
Palani, A [1 ]
Shapiro, S [1 ]
McBriar, MD [1 ]
Clader, JW [1 ]
Greenlee, WJ [1 ]
O'Neill, K [1 ]
Hawes, B [1 ]
机构：
[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 23期
关键词：
MCH-R1; antagonists; melanin concentrating hormone receptor 1 antagonists;
D O I：
10.1016/j.bmcl.2005.08.043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5234 / 5236
页数：3
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