The role of regulatory T lymphocytes in asthma pathogenesis

被引：33

作者：

Robinson, DS ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Biomed Sci Div,Leukocyte Biol Sect, London SW7 2AZ, England

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2005年 / 5卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/s11882-005-0087-8

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4(+)CD25(+) regulatory T cells, and interleukin (IL)-10 producing regulatory T cells may play a role in development of allergic sensitization. If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma.

引用

页码：136 / 141

页数：6

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