Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities

被引：3

作者：

Zhong Xiang-Jian ^{[1
]}

Zhou Na ^{[1
]}

Wang Xin ^{[1
]}

Li Jin-Jie ^{[1
]}

Ma Hui ^{[2
]}

Mao Yue ^{[1
]}

Xu Jia-Hui ^{[1
]}

Lin Peng-Cheng ^{[3
]}

Shang Xiao-Ya ^{[1
]}

机构：

[1] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

[2] Shandong Inst Prod Qual Inspect, Jinan 250100, Peoples R China

[3] Qinghai Nationalities Univ, Key Lab Qinghai Tibet Plateau Phytochem Qinghai P, Xining 810000, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2022年 / 20卷 / 02期

关键词：

Rosmarinus officinalis; Isolation and purification; Triterpenoid; Biological activity; CARNOSIC ACID; L;

D O I：

10.1016/S1875-5364(21)60103-6

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3 beta-hydroxyurs-12-en-20, 28-olide (2) and 3 beta-hy-droxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D-and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 mu g.mL(-1).

引用

页码：155 / 160

页数：6

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