Plant-derived alkaloids acting on dengue virus and their vectors: from chemistry to pharmacology

被引：1

作者：

Sarkar, Chandan ^{[1
]}

Quispe, Cristina ^{[2
]}

Islam, Muhammad T. ^{[3
]}

Jamaddar, Sarmin ^{[4
]}

Akram, Muhammad ^{[5
]}

Munior, Naveed ^{[6
]}

Martorell, Miquel ^{[7
]}

Kumar, Manoj ^{[8
]}

Sharifi-Rad, Javad ^{[9
]}

Cruz-Martins, Natalia ^{[10
,11
,12
]}

机构：

[1] Bangabandhu Sheikh Mujibur Rahman Sci & Technol U, Dept Pharm, Dhaka 8100, Bangladesh

[2] Univ Arturo Prat, Fac Ciencias Salud, Iquique 1110939, Chile

[3] Univ Arturo Prat, Fac Ciencias Salud, Iquique 1110939, Chile

[4] Bangabandhu Sheikh Mujibur Rahman Sci & Technol U, Life Sci Fac, Dept Pharm, Gopalganj 8100, Bangladesh

[5] Govt Coll Univ Faisalabad, Dept Eastern Med, Faisalabad, Pakistan

[6] Govt Coll Univ Faisalabad, Dept Biochem, Faisalabad, Pakistan

[7] Univ Concepcion, Dept Nutr & Dietet, Fac Pharm, Concepcion, Chile

[8] Univ Concepcion, Ctr Healthy Living, Concepcion, Chile

[9] ICAR Cent Inst Res Cotton Technol, Chem & Biochem Proc Div, Mumbai 400019, Maharashtra, India

[10] Univ Azuay, Fac Med, Cuenca, Ecuador

[11] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal

[12] Inst Res & Adv Training Hlth Sci & Technol CESPU, Rua Cent Gandra 1317, P-4585116 Gandra, PRD, Portugal

来源：

FUTURE MICROBIOLOGY | 2022年 / 17卷 / 02期

关键词：

Aedes; alkaloid; dengue; insecticidal; mosquito; CARICA-PAPAYA; LARVICIDAL ACTIVITY; ANTIVIRAL ACTIVITY; AEDES-AEGYPTI; IN-VITRO; INSECTICIDAL ACTIVITY; CARBAZOLE ALKALOIDS; UNCARIA-TOMENTOSA; EXTRACT; CONSTITUENTS;

D O I：

10.2217/fmb-2021-0002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.

引用

页码：143 / 155

页数：13

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