Synthesis and anti-bacterial activities of novel 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines and bis-(5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines)

被引：9

作者：

Vishwakarma, J. N. ^{[1
]}

Dutta, M. C. ^{[1
]}

Chanda, K. ^{[1
]}

Das, Bhaskar ^{[2
]}

Laskar, M. A. ^{[2
]}

Nongkhlaw, R. L. ^{[3
]}

机构：

[1] St Anthonys Coll, Dept Chem, Organ Res Lab, Shillong 793001, Meghalaya, India

[2] St Anthonys Coll, Dept Biotechnol, Shillong 793001, Meghalaya, India

[3] NE Hill Univ, Dept Chem, Shillong 793022, Meghalaya, India

来源：

ARKIVOC | 2009年

关键词：

4-Acetylpyridine; tetrahydropyrimidines; isonicotinoyl; bis-; ONE-POT SYNTHESIS;

D O I：

10.3998/ark.5550190.0010.d11

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines 4a-i have been synthesized in good yields by the reaction of enaminones 3a-c, primary amines and formaldehyde. 4a-i have been screened for their antibacterial properties. Enaminones 3a-c have also been reacted with diamines and formaldehyde to give hitherto unreported bis-tetrahydropyrimidines 5a-l in good yields. The structures of 4a-i and 5a-l have been established with the help of spectral and analytical data.

引用

页码：131 / 141

页数：11

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