Virus neutralization study using H120, H52, 793/B antisera against Iranian infectious bronchitis virus genotypes

被引：1

作者：

Zabihipetroudi, M. T. ^{[1
]}

Ghalyanchilangeroudi, A. ^{[2
]}

Karimi, V ^{[1
]}

Khaltabadifarahani, R. ^{[3
]}

Hashemzadeh, M. ^{[4
]}

机构：

[1] Univ Tehran, Fac Vet Med, Dept Poultry Dis, Tehran, Iran

[2] Univ Tehran, Fac Vet Med, Dept Microbiol & Immunol, Tehran, Iran

[3] Iranian Vet Org, Tehran, Iran

[4] Razi Vaccine & Serum Res Inst, Dept Res & Prod Poultry Viral Vaccine, Razi Vaccine, Iran

来源：

ACTA VIROLOGICA | 2018年 / 62卷 / 04期

关键词：

avian infectious bronchitis; Iran; virus neutralization; S1; GENE; STRAINS; SPIKE; VACCINATION; VARIANTS; EFFICACY; CHINA;

D O I：

10.4149/av_2018_404

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Infectious bronchitis virus (IBV), a major pathogen of the domestic fowl, exhibits extensive antigenic variation. IBV is a member of the Coronaviridae family and the genus Gammacoronavirus. A new infectious bronchitis virus serotype can emerge from only very few amino acid changes within the major peplomer glycoprotein, namely in its S1 part forming the virion spike. Principally, the serotypes are identified by virus neutralization (VN) tests. This study is aimed to investigate the neutralizing efficiency of H52, H120, and 4/91 antiserum against IBV genotypes (IS-1494, IS-720, 793/B, IR-I) recently circulating in Iran. For the first time, we have used cross-neutralization tests for the serological classification of these isolates. In this study, all antisera failed to neutralize all IBV strains. According to the results of our research, cross-protection studies are necessary for the design of a proper vaccination program for IBV circulating genotypes in Iran. The data are useful for the development of new vaccine strategies.

引用

页码：374 / 378

页数：5

共 42 条

[41] Synthesis of isomeric 4-(N-methyltetrazolylamino)-2-phenyl-4H-thiopyrano[2,3-b]quinoline-3-carbaldehydes and 4-hydroxy-2-phenyl-4H-thiopyrano[2,3-b]quinoline-3-carbaldehyde based on tandem thiol-Michael and (aza)-Morita–Baylis–Hillman reactions and an in vitro study of the activity of the obtained compounds against influenza virus
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Mariya А. Skryl’nikova
Yuliya N. Pavlyukova
Vladimir V. Zarubaev
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[42] Synthesis of isomeric 4-(N-methyltetrazolylamino)-2-phenyl-4H-thiopyrano[2,3-b]quinoline-3-carbaldehydes and 4-hydroxy-2-phenyl-4H-thiopyrano[2,3-b]quinoline-3-carbaldehyde based on tandem thiol-Michael and (aza)-Morita-Baylis-Hillman reactions and an in vitro study of the activity of the obtained compounds against influenza virus
Khramchikhin, Andrey V.
Skryl'nikova, Mariya A.
Pavlyukova, Yuliya N.
Zarubaev, Vladimir V.
Esaulkova, Yana L.
Muryleva, Anna A.
Shmanyova, Nadezhda T.
Danagulyan, Gevorg G.
Ostrovskii, Vladimir A.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2022, 58 (4-5) : 267 - 270

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