Phosphodiester hydrolysis promoted by dinuclear iron(III) complexes

被引：0

作者：

Piovezan, Clovis ^{[1
]}

Lisboa, Fabio da Silva ^{[1
]}

Nunes, Fabio Souza ^{[1
]}

Drechsel, Sueli Maria ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Quim, Lab Quim Bioinorgan & Catalise, BR-81531970 Curitiba, Parana, Brazil

来源：

TRANSITION METAL CHEMISTRY | 2011年 / 36卷 / 01期

关键词：

PURPLE ACID-PHOSPHATASES; BIS(2,4-DINITROPHENYL) PHOSPHATE; BINUCLEATING LIGAND; MODEL COMPOUNDS; MULTIPLE FORMS; BINDING-SITE; ACTIVE-SITE; PURIFICATION; UTEROFERRIN; RESONANCE;

D O I：

10.1007/s11243-010-9437-z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report the reactivity of three binuclear non-heme Fe(III) compounds, namely [Fe-2(bbppnol)(mu-AcO)(H2O)(2)](ClO4)(2) (1), [Fe-2(bbppnol)(mu-AcO)(2)](PF6) (2), and [Fe-2(bbppnol)(mu-OH)(Cl)(2)]center dot 6H(2)O (3), where H(3)bbppnol = N,N'-bis(2-hydroxybenzyl)-N,N'-bis(2-methylpyridyl)-1,3-propanediamine-2-ol, toward the hydrolysis of bis-(2,4-dinitrophenyl)phosphate as models for phosphoesterase activity. The synthesis and characterization of the new complexes 1 and 3 was also described. The reactivity differences observed for these complexes show that the accessibility of the substrate to the reaction site is one of the key steps that determinate the hydrolysis efficiency.

引用

页码：79 / 85

页数：7

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