CDK8/19 inhibition overcomes in vitro and in vivo resistance to lapatinib in HER2+breast cancer via STAT1 and STAT3.

被引:0
|
作者
Ding, Xiaokai [1 ]
Sharko, Amanda C. [1 ]
McDermott, Martina S-J [1 ]
Ji, Hao [1 ]
Chumanevich, Alexander [1 ]
Schools, Gary P. [1 ]
Mack, Zachary T. [1 ]
Pugacheva, Elena [2 ]
Tatarskiy, Victor [3 ]
Khrustaleva, Anastasia [3 ]
Tyakht, Alexander [3 ]
Shtutman, Michael [1 ]
Chen, Mengqian [4 ]
Roninson, Igor [1 ]
Broude, Eugenia V. [1 ]
机构
[1] Univ South Carolina, Coll Pharm, Columbia, SC 29208 USA
[2] West Virginia Univ, Sch Med, Morgantown, WV 26506 USA
[3] Russian Acad Sci, Inst Gene Biol, Moscow, Russia
[4] Senex Biotechnol, Columbia, SC USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LB132
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Inhibition of the autocrine IL6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+breast cancers
    Silva, J.
    Rodriguez-Barrueco, R.
    Yu, J.
    Kalinsky, K.
    Maurer, M.
    Califano, A.
    CANCER RESEARCH, 2016, 76
  • [22] Evaluating the role of CDK4/6 inhibition on STAT3 activation in a transgenic mouse model of HER2-positive breast cancer
    Adesoye, Taiwo
    Luo, Linjie
    Bui, Tuyen
    Kim, Serena
    Wingate, Hannah
    Tripathy, Debu
    Hunt, Kelly
    Keyomarsi, Khandan
    CANCER RESEARCH, 2024, 84 (09)
  • [23] Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis
    Spear, Jensen M.
    Lu, Zhixin
    Russu, Wade A.
    MOLECULES, 2020, 25 (23):
  • [24] IL-8 secreted by tumor associated macrophages contribute to lapatinib resistance in HER2-positive locally advanced breast cancer via activation of Src/STAT3/ERK1/2-mediated EGFR signaling
    Ahmed, Shaza
    Mohamed, Hossam Taha
    El-Husseiny, Noura
    El Mahdy, Manal M.
    Safwat, Gehan
    Diab, Ayman A.
    El-Sherif, Ahmed A.
    El-Shinawi, Mohamed
    Mohamed, Mona Mostafa
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 1868 (06):
  • [25] Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo
    Judd, Louise M.
    Menheniott, Treve R.
    Ling, Hui
    Jackson, Cameron B.
    Howlett, Meegan
    Kalantzis, Anastasia
    Priebe, Waldemar
    Giraud, Andrew S.
    PLOS ONE, 2014, 9 (05):
  • [26] MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway
    Lv, Yuanyuan
    Li, Yang
    Wang, Jiangya
    Li, Mei
    Zhang, Wenhao
    Zhang, Huifen
    Shen, Ying
    Li, Chao
    Du, Yuan
    Jiang, Lian
    GENES TO CELLS, 2021, 26 (10) : 772 - 781
  • [27] NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer
    Lili Jiang
    Liangliang Ren
    Han Chen
    Jinyuan Pan
    Zhuojun Zhang
    Xiangqin Kuang
    Xuhong Chen
    Wenhao Bao
    Chun Lin
    Zhongqiu Zhou
    Danping Huang
    Jianan Yang
    Hongbiao Huang
    Lan Wang
    Ning Hou
    Libing Song
    Cell Death & Disease, 11
  • [28] NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer
    Jiang, Lili
    Ren, Liangliang
    Chen, Han
    Pan, Jinyuan
    Zhang, Zhuojun
    Kuang, Xiangqin
    Chen, Xuhong
    Bao, Wenhao
    Lin, Chun
    Zhou, Zhongqiu
    Huang, Danping
    Yang, Jianan
    Huang, Hongbiao
    Wang, Lan
    Hou, Ning
    Song, Libing
    CELL DEATH & DISEASE, 2020, 11 (07)
  • [29] PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer
    Zhang, Hongyan
    Zhang, Longlong
    He, Yuna
    Jiang, Dewei
    Sun, Jian
    Luo, Qianmei
    Liang, Huichun
    Wang, Tiantian
    Li, Fubing
    Tang, Yu
    Yang, Zimo
    Liu, Wenjing
    Rao, Yu
    Chen, Ceshi
    CANCER LETTERS, 2024, 598
  • [30] Functionalized nanoscale β-1,3-glucan to improve Her2+breast cancer therapy: In vitro and in vivo study
    Nasrollahi, Zahra
    Mohammadi, Shahla Roudbar
    Mollarazi, Esmail
    Yadegari, Mohammad Hossein
    Hassan, Zuhair Mohammad
    Talaei, Fatemeh
    Dinarvand, Rassoul
    Akbari, Hassan
    Atyabi, Fatemeh
    JOURNAL OF CONTROLLED RELEASE, 2015, 202 : 49 - 56