Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex

被引：24
|
作者：
Bani, S
Kaul, A
Jaggi, BS
Suri, KA
Suri, OP
Sharma, OP
机构：
[1] Reg Res Lab, Dept Pharmacol, Jammu 180001, India
[2] Reg Res Lab, Nat Prod Chem Div, Jammu 180001, India
[3] Univ Jammu, Dept Biosci, Jammu 180004, India
来源：
FITOTERAPIA | 2000年 / 71卷 / 06期
关键词：
Euphorbia royleana; anti-inflammatory activity; anti-arthritic activity;
D O I：
10.1016/S0367-326X(00)00225-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD50 was more than 1500 mg/kg in both rats and mice. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：655 / 662
页数：8
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