5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation

被引:52
|
作者
Lonsdorf, Tina B. [1 ,2 ,3 ,4 ]
Golkar, Armita [1 ,3 ,4 ]
Lindstom, Kara M. [1 ,5 ]
Fransson, Peter [1 ,3 ]
Schalling, Martin [2 ]
Ohman, Arne [1 ,3 ,4 ]
Ingvar, Martin [1 ,3 ,4 ,6 ]
机构
[1] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
[2] Karolinska Inst, Ctr Mol Med & Surg, Neurogenet Sect, Stockholm, Sweden
[3] Karolinska Inst, Stockholm Brain Inst, Stockholm, Sweden
[4] Karolinska Inst, Nord Ctr Excellence Cognit Control, Stockholm, Sweden
[5] Karolinska Inst, Mood & Anxiety Program, NIMH, NIH, Stockholm, Sweden
[6] Osher Ctr Integrat Med, NIH Ctr Study Emot & Attent, Stockholm, Sweden
关键词
Polymorphism; Amygdala habituation; Laterality; Imaging genetics; 5-HTTLPR; COMTval158met; METHYLTRANSFERASE VAL(158)MET GENOTYPE; SEROTONIN TRANSPORTER; FACIAL EXPRESSIONS; BIASED ATTENTION; PREFRONTAL CORTEX; POLYMORPHISM; ANXIETY; FEAR; ASSOCIATION; ACTIVATION;
D O I
10.1016/j.biopsycho.2011.02.014
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMT-val158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using the a priori anatomical region of interest (ROI) approach. Furthermore, salivary cortisol and skin conductance responses were recorded. We observed an effect of 5-HTTLPR on right amygdala reactivity (s-carrier > 1/l) and COMTval158met on left amygdala reactivity (met/met > val-carrier). We provide preliminary evidence that different amygdala habituation curves may partly underlie the differences between 5-HTTLPR and not COMT genotype groups. Further, exploratory analyses find no evidence for additive or interaction effects. Our results support that 5-HTTLPR s-carriers and COMT met/met carriers may be more sensitive to the detection of biologically and socially relevant information and suggest a mechanism behind this for the 5-HTTLPR. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:106 / 112
页数:7
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