Osteosarcoma is the most common primary malignancy of bone. Although outcomes of patients with osteosarcoma have improved since the introduction of chemotherapy, outcomes of metastatic or unresectable osteosarcomas are still unsatisfactory. To improve osteosarcoma outcomes, the development of novel systemic therapies for osteosarcoma is needed. Since the 1880s, various immunotherapies have been utilized in patients with osteosarcoma and some patients have shown response to the treatment. Based on recent studies about the role of the immune system in malignancies, immunotherapies including immune modulators such as interleukin-2 and muramyl tripeptide, dendritic cells, immune checkpoint inhibitors, and engineered T cells have been utilized in patients with malignancies. Although there are limited reports of immunotherapies for osteosarcoma, immunotherapy is thought to be a promising treatment option for treating osteosarcomas. In this review, an overview of various immunotherapies for osteosarcoma is provided and their potential as adjuvant therapies is discussed.
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Cheng, Hongyan
Zong, Liju
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Zong, Liju
Kong, Yujia
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Kong, Yujia
Gu, Yu
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Gu, Yu
Yang, Junjun
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Yang, Junjun
Xiang, Yang
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
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Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China
Zhu, Hao-Hua
Feng, Yu
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Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China
Feng, Yu
Hu, Xing-Sheng
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Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China
机构:
Univ Calif San Francisco, Dept Med Hematol Oncol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Melanoma Clin Res, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med Hematol Oncol, San Francisco, CA 94143 USA