Synthesis and biological activity of 4-chloromethyl-substituted 1,3,2-dioxaphosphorinanes phosphates and amidophosphates

被引：1
|
作者：
Koroteev, AM [1 ]
Krasnov, GB [1 ]
Koroteev, MP [1 ]
Nifantyev, EE [1 ]
机构：
[1] Moscow State Pedag Univ, Moscow 119992, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 39卷 / 04期
关键词：
D O I：
10.1023/A:1026080422837
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-N and 2-O-substituted 2-oxo-4-chloromethyl-1,3,2-dioxaphosphorinaiies were prepared by reaction of amines and alcohols with 2-oxo-2-chloro-4-chloromethyl- 1,3,2-dioxaphosphorinane. The structure of compounds obtained was proved by means of H-1 and C-13 NMR spectroscopy. Some cyclic amidocyclophosphates possessed biological activity as inhibitors of mitotic fission and of Na+/H+ exchange.
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页码：601 / 608
页数：8
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