Sinus node dysfunction following targeted disruption of the cardiac sodium channel gene, Scn5a

被引:0
|
作者
Lei, M
Goddard, C
Liu, J
Léoni, AL
Royer, A
Fung, S
Zhang, HG
Charpentier, F
Vandenberg, I
Colledge, W
Grace, A
Huang, C
机构
[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England
[2] Univ Cambridge, Dept Physiol, Cambridge, England
[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England
[4] INSERM, U533, Fac Med, Nantes, France
[5] UMIST, Dept Phys, Manchester M60 1QD, Lancs, England
[6] Victor Chang Cardiac Res Inst, Darlinghurst, NSW, Australia
来源
FASEB JOURNAL | 2005年 / 19卷 / 04期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:A201 / A201
页数:1
相关论文
共 50 条
  • [41] A mutation in the cardiac pacemaker channel gene causes sinus node dysfunction.
    Schulze-Bahr, E
    Neu, A
    Friederich, P
    Kaupp, BU
    Pongs, O
    Isbrandt, D
    CIRCULATION, 2001, 104 (17) : 192 - 192
  • [42] Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture
    Chiang, David Y.
    Kim, Jeffrey J.
    Valdes, Santiago O.
    de la Uz, Caridad
    Fan, Yuxin
    Orcutt, Jeffrey
    Domino, Melissa
    Smith, Melissa
    Wehrens, Xander H. T.
    Miyake, Christina Y.
    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2015, 8 (05): : 1105 - 1112
  • [43] Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation
    Remme, C. A.
    Verkerk, A. O.
    Wilde, A. A. M.
    Veldkamp, M. W.
    de Bakker, J. M. T.
    Bezzina, C. R.
    NETHERLANDS HEART JOURNAL, 2007, 15 (06) : 235 - 238
  • [44] Study of the cardiac sodium channel in a mouse model of Scn5a haploinsufficiency towards a novel approach of therapy
    Ferrand, M.
    Mougenot, N.
    Laporte, P-L
    Leclerc, A.
    Algalarrondo, V
    Extramiana, F.
    Charpentier, F.
    Neyroud, N.
    CARDIOVASCULAR RESEARCH, 2024, 120
  • [45] Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation
    C. A. Remme
    A. O. Verkerk
    A. A. M. Wilde
    M. W. Veldkamp
    J. M. T. de Bakker
    C. R. Bezzina
    Netherlands Heart Journal, 2007, 15 : 235 - 238
  • [46] Response to letter regarding article, "Cardiac Sodium Channel (SCN5A) Variants Associated with Atrial Fibrillation"
    Darbar, Dawood
    Kucera, Gayle
    Stubblefield, Tanya
    George, Alfred L., Jr.
    Roden, Dan M.
    Kannankeril, Prince J.
    Donahue, Brian S.
    Haines, Jonathan L.
    CIRCULATION, 2008, 118 (16) : E669 - E669
  • [47] Tandem promoters and developmentally regulated 5′- and 3′-mRNA untranslated regions of the mouse Scn5a cardiac sodium channel
    Shang, LJL
    Dudley, SC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (02) : 933 - 940
  • [48] A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit (SCN5A) Gene Is Associated with Sudden Cardiac Death in Chronic Ischemic Heart Disease
    Marcsa, Boglarka
    Denes, Reka
    Voeroes, Krisztina
    Racz, Gergely
    Sasvari-Szekely, Maria
    Ronai, Zsolt
    Toero, Klara
    Keszler, Gergely
    PLOS ONE, 2015, 10 (07):
  • [49] Beat-to-beat repolarization variability in LQTS patients with the SCN5A sodium channel gene mutation
    Couderc, JP
    Zareba, W
    Burattini, L
    Moss, AJ
    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1999, 22 (11): : 1581 - 1592
  • [50] TGF-β1-Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms in Producing the Sinus Node Dysfunction Associated With SCN5A Deficiency and Aging
    Hao, Xiaojin
    Zhang, Yanmin
    Zhang, Xinzhao
    Nirmalan, Mahesh
    Davies, Laura
    Konstantinou, Dimitrios
    Yin, Fei
    Dobrzynski, Halina
    Wang, Xin
    Grace, Andrew
    Zhang, Henggui
    Boyett, Mark
    Huang, Christopher L. -H.
    Lei, Ming
    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2011, 4 (03): : 397 - U231