Cognitive impairment and morphological changes after radiation therapy in brain tumors: A review

被引：54

作者：

Jacob, Julian ^{[1
,2
]}

Durand, Thomas ^{[2
,3
]}

Feuvret, Loic ^{[1
]}

Mazeron, Jean-Jacques ^{[1
]}

Delattre, Jean-Yves ^{[3
,4
]}

Khe Hoang-Xuan ^{[3
,4
]}

Psimaras, Dimitri ^{[3
,4
]}

Douzane, Hassen ^{[3
]}

Ribeiro, Monica ^{[2
,3
]}

Capelle, Laurent ^{[5
]}

Carpentier, Alexandre ^{[4
,5
]}

Ricard, Damien ^{[2
,6
,7
]}

Maingon, Philippe ^{[1
]}

机构：

[1] Sorbonne Univ, Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Dept Radiat Oncol, Paris, France

[2] Sorbonne Univ, CNRS, Serv Sante Armees, Cognit & Act Grp, Paris, France

[3] Sorbonne Univ, Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Dept Neurol, Paris, France

[4] Sorbonne Univ, INSERM, AP HP, CNRS,Inst Cerveau & Moelle Epiniere, Paris, France

[5] Sorbonne Univ, Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Dept Neurosurg, Paris, France

[6] Hop Instruct Armees Percy, Serv Sante Armees, Dept Neurol, Clamart, France

[7] Ecole Val de Grace, Serv Sante Armees, Paris, France

来源：

RADIOTHERAPY AND ONCOLOGY | 2018年 / 128卷 / 02期

关键词：

Brain; Radiotherapy; Cognition; Toxicity; Radiosensitivity; PROPHYLACTIC CRANIAL IRRADIATION; APPEARING WHITE-MATTER; CENTRAL-NERVOUS-SYSTEM; VENTRICULAR-SUBVENTRICULAR ZONE; SIMULTANEOUS INTEGRATED BOOST; STEM-CELL COMPARTMENT; MODULATED ARC THERAPY; HIGH-GRADE GLIOMA; ADULT NEUROGENESIS; GLIOBLASTOMA-MULTIFORME;

D O I：

10.1016/j.radonc.2018.05.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Life expectancy of patients treated for brain tumors has lengthened due to the therapeutic improvements. Cognitive impairment has been described following brain radiotherapy, but the mechanisms leading to this adverse event remain mostly unknown. Technical evolutions aim at enhancing the therapeutic ratio. Sparing of the healthy tissues has been improved using various approaches; however, few dose constraints have been established regarding brain structures associated with cognitive functions. The aims of this literature review are to report the main brain areas involved in cognitive adverse effects induced by radiotherapy as described in literature, to better understand brain radiosensitivity and to describe potential future improvements. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：221 / 228

页数：8

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