The societal impact of early intensified treatment in patients with type 2 diabetes mellitus

被引：7

作者：

Tsotra, Foteini ^{[1
]}

Kappel, Mathias ^{[2
]}

Peristeris, Platon ^{[1
]}

Bader, Giovanni ^{[3
]}

Levi, Eva ^{[1
]}

Lister, Nicola ^{[4
]}

Malhotra, Ankur ^{[5
]}

Ostwald, Dennis A. ^{[2
,6
]}

机构：

[1] WifOR Inst, Athens, Greece

[2] WifOR Inst, Darmstadt, Germany

[3] Novartis Pharma AG, Basel, Switzerland

[4] Novartis Global Hlth & Sustainabil, Johannesburg, South Africa

[5] Novartis India Ltd, Mumbai, Maharashtra, India

[6] Steinbeis Univ, Grad Sch, SIBE, Fac Leadership & Management, Berlin, Germany

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2022年 / 11卷 / 16期

关键词：

antidiabetes treatment; diabetes complications; early intensified treatment; metformin monotherapy; productivity costs; societal impact; type 2 diabetes mellitus; CARDIOVASCULAR OUTCOMES; GLUCOSE CONTROL; WORK; RETURN; PREVALENCE; INSULIN; RISK;

D O I：

10.2217/cer-2022-0110

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Aim: The current study estimates the societal impact of early intensified treatment compared with initial monotherapy with subsequent treatment intensification in newly diagnosed adults with type 2 diabetes mellitus in Mexico. Methods: An individual patient-level simulation and a static cohort model were employed to simulate the treatment pathway and the probability of experiencing complications of diabetes. The avoided number of events was translated into avoided productivity losses, which were monetized using wages. Results: Patients on early intensified treatment experienced approximately 13,000 fewer complication events over 10 years. This was translated into a societal impact of $54 million (USD). Conclusion: Early treatment intensification is likely to be of particular benefit to health outcomes and productivity losses.

引用

页码：1185 / 1199

页数：15

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