Cell biology of bladder development and the role of the extracellular matrix

被引：3
|
作者：
McCarthy, LSL [1 ]
Smeulders, N [1 ]
Wilcox, DT [1 ]
机构：
[1] UCL, Inst Child Hlth, Nephrourol Unit, London WC1N 1EH, England
来源：
NEPHRON EXPERIMENTAL NEPHROLOGY | 2003年 / 95卷 / 04期
关键词：
detrusor; extracellular matrix; integrin; fibronectin; laminin; proliferation; smooth muscle;
D O I：
10.1159/000074839
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The bladder is unique. It is the most distensible organ in the body. If the normal pattern of development is disturbed, the bladder can become dysfunctional and poorly compliant. Renal outcome is intimately linked to bladder function and hence bladder development. In this review we describe our current knowledge of the molecular processes that govern bladder development, with particular emphasis on the role of the extracellular matrix. Finally, we suggest a hypothetical model for bladder development. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码：E129 / E133
页数：5
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