Experimental studies of the microangioarchitecture of tumors using synchrotron radiation at SPring-8

被引：3
|
作者：
Yamashita, T [1 ]
Imai, S [1 ]
Maehara, N [1 ]
Kajihara, Y [1 ]
Umetani, K [1 ]
机构：
[1] Kawasaki Med Sch, Dept Diagnost Radiol, Kurashiki, Okayama 7010192, Japan
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2001年 / 467卷
关键词：
synchrotron radiation; microangiography; microangioarchitecture; VX2; tumor; tumor vessel;
D O I：
10.1016/S0168-9002(01)00660-X
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
The purpose of the present study was to compare differences in the depiction of small vessels in tumors on microangiograms obtained with a conventional soft X-ray system and with a synchrotron radiation (SR) system, and to evaluate the microangioarchitecture of these tumors and the process of their growth neovascularization. The SR system consisted of a monochromatic X-ray source of 37.6keV just above the K absorption edge of barium and two fluorescent-screen CCD-camera lens-coupling systems. One of the CCD systems had a 24 mum equivalent pixel size and an input field size of 24 x 24 mm. The other system had a 6 mum equivalent pixel size and an input field of 6 x 6 mm. Microangiograms using the soft X-ray system depicted small vessels (diameter 20-50 mum), but the microangioarchitecture of the tumors could not be evaluated from conventional images. The monochromatic SR system allowed depiction of small vessels with a diameter of less than 25 mum. In addition, this system allowed us to confirm the process of growth neovascularization in the tumors. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：1346 / 1348
页数：3
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