Input Overload: Contributions of Retinoic Acid Signaling Feedback Mechanisms to Heart Development and Teratogenesis

被引：33
|
作者：
D'Aniello, Enrico
Waxman, Joshua S. [1 ,2 ]
机构：
[1] Cincinnati Childrens Res Fdn, Mol Cardiovasc Biol Div, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Res Fdn, Inst Heart, Cincinnati, OH 45229 USA
来源：
DEVELOPMENTAL DYNAMICS | 2015年 / 244卷 / 03期
关键词：
retinoic acid; vitamin A; development; signaling feedback; transcriptional regulation; teratogenesis; vertebrates; heart; cardiac progenitors; patterning; morphogen; CENTRAL-NERVOUS-SYSTEM; VITAMIN-A HOMEOSTASIS; MATTHEW-WOOD-SYNDROME; RAR DOUBLE MUTANTS; BINDING-PROTEIN-I; ACTIVE REPRESSION; MOUSE DEVELOPMENT; CYP26; ENZYMES; TARGET GENES; ALL-TRANS;
D O I：
10.1002/dvdy.24232
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Appropriate levels of retinoic acid (RA) signaling are critical for normal heart development in vertebrates. A fascinating property of RA signaling is the thoroughness by which positive and negative feedback are employed to promote proper embryonic RA levels. In the present short review, we first cover the advancement of hypotheses regarding the impact of RA signaling on cardiac specification. We then discuss our current understanding of RA signaling feedback mechanisms and the implications of recent studies, which have indicated improperly maintained RA signaling feedback can be a contributing factor to developmental malformations. Developmental Dynamics 244:513-523, 2015. (c) 2014 Wiley Periodicals, Inc.
引用
收藏
页码：513 / 523
页数：11
相关论文
共 50 条
  • [41] THE ROLE OF RETINOIC ACID SIGNALING IN HUMAN DEFINITIVE HEMATOPOIETIC MESODERM DEVELOPMENT
    Fernandez, Nestor
    Durland, Lauren
    Atkins, Michael
    Garcia, Analucia
    Keller, Gordon
    Kennedy, Marion
    Sturgeon, Christopher
    EXPERIMENTAL HEMATOLOGY, 2024, 137
  • [42] Towards a Better Vision of Retinoic Acid Signaling during Eye Development
    Duester, Gregg
    CELLS, 2022, 11 (03)
  • [43] Mechanisms of retinoic acid signalling and its roles in organ and limb development
    Cunningham, Thomas J.
    Duester, Gregg
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (02) : 110 - 123
  • [44] Mechanisms of retinoic acid signalling and its roles in organ and limb development
    Thomas J. Cunningham
    Gregg Duester
    Nature Reviews Molecular Cell Biology, 2015, 16 : 110 - 123
  • [45] Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation
    Sorrell, Mollie R. Johnson
    Waxman, Joshua S.
    DEVELOPMENTAL BIOLOGY, 2011, 358 (01) : 44 - 55
  • [46] Retinoic acid signaling is critical during the totipotency window in early mammalian development
    Ane Iturbide
    Mayra L. Ruiz Tejada Segura
    Camille Noll
    Kenji Schorpp
    Ina Rothenaigner
    Elias R. Ruiz-Morales
    Gabriele Lubatti
    Ahmed Agami
    Kamyar Hadian
    Antonio Scialdone
    Maria-Elena Torres-Padilla
    Nature Structural & Molecular Biology, 2021, 28 : 521 - 532
  • [47] Visualization, of retinoic acid signaling in transgenic axolotls during limb development and regeneration
    Monaghan, James R.
    Maden, Malcolm
    DEVELOPMENTAL BIOLOGY, 2012, 368 (01) : 63 - 75
  • [48] Retinoic Acid Signaling in Development: Tissue-Specific Functions and Evolutionary Origins
    Campo-Paysaa, Florent
    Marletaz, Ferdinand
    Laudet, Vincent
    Schubert, Michael
    GENESIS, 2008, 46 (11) : 640 - 656
  • [49] Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development
    Stafford, D
    Prince, VE
    CURRENT BIOLOGY, 2002, 12 (14) : 1215 - 1220
  • [50] Interactions Between Retinoic Acid and Wnt Signaling During Photoreceptor Development in Zebrafish
    Stevens, C. B.
    Hunter, S.
    Stenkamp, D.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
12345