Tocilizumab in Giant Cell Arteritis: A Multicenter Retrospective Study of 34 Patients

被引：48

作者：

Regent, Alexis ^{[1
]}

Redeker, Serge ^{[2
]}

Deroux, Alban ^{[3
]}

Kieffer, Pierre ^{[4
]}

Ly, Kim Heang ^{[5
]}

Dougados, Maxime ^{[6
]}

Liozon, Eric ^{[5
]}

Larroche, Claire ^{[7
]}

Guillevin, Loic ^{[1
]}

Bouillet, Laurence ^{[3
]}

Espitia, Olivier ^{[8
]}

Costedoat-Chalumeau, Nathalie ^{[1
]}

Soubrier, Martin ^{[9
]}

Brihaye, Benoit ^{[10
]}

Lifermann, Francois ^{[11
]}

Lefevre, Guillaume ^{[12
]}

Puechal, Xavier ^{[13
,14
]}

Mouthon, Luc ^{[13
,14
]}

Toussirot, Eric ^{[15
]}

机构：

[1] Univ Paris 05, Hop Cochin, APHP, Ctr Reference Malad Autoimmunes & Syst Rares,Serv, Paris, France

[2] Ctr Hosp Abbeville, Serv Med Interne, Abbeville, France

[3] Univ Grenoble Alpes, Serv Med Interne, CHU Grenoble, Grenoble, France

[4] Ctr Hosp Gen Mulhouse, Serv Med Interne, Mulhouse, France

[5] CHU Limoges, Serv Med Interne, Limoges, France

[6] Univ Paris 05, Hop Cochin, APHP,INSERM,PRES Sorbonne Paris Cite, Clin Epidemiol & Biostat,Dept Rheumatol,U1153, Paris, France

[7] Hop Avicenne, Serv Med Interne, Avicenne, France

[8] Hop Hotel Dieu, Serv Med Interne, Paris, France

[9] CHU Clermont Ferrand, Serv Rhumatol, Clermont Ferrand, France

[10] Hop St Quentin, Serv Med Interne & Med Polyvalente, Paris, France

[11] CH Dax, Serv Med Interne, Dax, France

[12] Hop Claude Huriez, Serv Med Interne, Paris, France

[13] Univ Paris 05, Paris, France

[14] Hop Cochin, APHP, Serv Med Interne, Ctr Reference Malad Autoimmunes & Syst Rares, Paris, France

[15] CHRU, INSERM CIC 1431, FHU INCREASE,Serv Rhumatol, Ctr Invest Clin Biotherapie, Paris, France

来源：

JOURNAL OF RHEUMATOLOGY | 2016年 / 43卷 / 08期

关键词：

GIANT CELL ARTERITIS; TOCILIZUMAB; BIOLOGICAL THERAPY; LARGE-VESSEL VASCULITIS; INTERLEUKIN-6;

D O I：

10.3899/jrheum.151252

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To report the efficacy and safety of tocilizumab (TCZ) for giant cell arteritis (GCA). Methods. A retrospective multicenter study that included 34 patients receiving TCZ for GCA. Results. TCZ was effective in all but 6 patients, who still had mild symptoms. Mean glucocorticoid dose was tapered. One patient died and 3 patients had to stop TCZ therapy because of severe adverse events. Twenty-three patients stopped treatment; 8 of these experienced relapses after a mean of 3.5 +/- 1.3 months. Conclusion. TCZ is effective in GCA. However, side effects occur. Whether this treatment has only a suspensive effect remains to be determined.

引用

页码：1547 / 1552

页数：6

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