Overexpression of CuZnSOD gene suppresses the growth of hepatocellular cancer cell line HepG2

被引：0
|
作者：
Bai, JX [1 ]
Zhu, XG
Zheng, XC
Wu, YJ
机构：
[1] Beijing Med Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China
[2] Beijing Med Univ, Dept Pathophysiol, Beijing 100083, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 1998年 / 111卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective To explore the inhibiting effect of superoxide dismutase (SOD) on the growth of hepatocellular cancer cell line HepG2. Methods By gene transfer technique, hepatocellular cancer cells (HepG2) were transfected with a retroviral vector containing human CuZnSOD cDNA. The elevated SOD gene expression of the transfected cells was compared with the parental and neo control cells. Results Compared to the control cells, cancer cells transfected with SOD gene showed an inhibited cell growth, a reduced number of cells in S phase and decreased clone forming ability in soft agar, as well as a smaller tumor size formed in nude mice. Conclusion The overexpression of CuZnSOD gene could, to certain extent, suppress the cell growth of hepatocellular cancer cell line HepG2.
引用
收藏
页码：789 / 792
页数：4
相关论文
共 50 条
  • [31] Study of the efficacy of photofrinA®-Mediated PDT on human hepatocellular carcinoma (HepG2) cell line
    Atif, M.
    Fakhar-e-Alam, M.
    Zaidi, S. S. Z.
    Suleman, R.
    LASER PHYSICS, 2011, 21 (06) : 1135 - 1144
  • [32] Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line
    Ahmadian, Elham
    Dizaj, Solmaz Maleki
    Rahimpour, Elaheh
    Hasanzadeh, Amir
    Eftekhari, Aziz
    Zadegan, Hasan Hosain
    Halajzadeh, Jamal
    Ahmadian, Hale
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2018, 93 : 465 - 471
  • [33] Effect of miR-4270 Suppression on Migration in Hepatocellular Carcinoma Cell Line (HepG2)
    Akrami, Hassan
    Gholami, Hanieh
    Fattahi, Mohammad Reza
    Zeraatiannejad, Mastaneh
    IRANIAN BIOMEDICAL JOURNAL, 2023, 27 (04) : 167 - 172
  • [34] DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line
    Walter J.Curran
    George Iliakis
    World Journal of Gastroenterology, 2002, 8 (05) : 797 - 803
  • [35] DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line
    Zeng, ZC
    Jiang, GL
    Wang, GM
    Tang, ZY
    Curran, WJ
    Iliakis, G
    WORLD JOURNAL OF GASTROENTEROLOGY, 2002, 8 (05) : 797 - 803
  • [36] Cytotoxic and apoptotic effects of the Adenium obesum extract on the hepatocellular carcinoma cell line (HepG2)
    Hajinourmohammadi, Ashkan
    Zargan, Jamil
    Jafary, Hanieh
    Ebrahimi, Firouz
    GENE REPORTS, 2024, 35
  • [37] Cortistatin production by HepG2 human hepatocellular carcinoma cell line and distribution of somatostatin receptors
    Notas, G
    Kolios, G
    Mastrodimou, N
    Kampa, M
    Vasilaki, A
    Xidakis, C
    Castanas, E
    Thermos, K
    Kouroumalis, E
    JOURNAL OF HEPATOLOGY, 2004, 40 (05) : 792 - 798
  • [38] Effect of EGCG on fatty acid synthase expression in hepatocellular carcinoma cell line HepG2
    Hong, Li
    Gang, Zhao
    Lei, Dong
    Lan, Luxiao
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 : 912 - 912
  • [39] Characterization of Cepharanthin Nanosuspensions and Evaluation of Their In Vitro Activity for the HepG2 Hepatocellular Carcinoma Cell Line
    Zhao, Yue
    Fu, Tingting
    Meng, Gaoke
    Qiao, Fangxia
    Hou, Yanhui
    Liu, Yanhua
    Yang, Jianhong
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (18) : 2293 - 2303
  • [40] The inhibition of acetyl CoA carboxylase by metformin in the human hepatocellular carcinoma cell line HepG2
    Peng, Xiaoren
    Liu, Yan
    Zou, Dajin
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2015, 31 : 3 - 3
12345