DRUG METABOLITES POTENTLY INHIBIT RENAL ORGANIC ANION TRANSPORTERS, OAT1 AND OAT3

被引:0
|
作者
Zou, L. [1 ]
Stecula, A. [1 ]
Giacomini, K. [1 ]
机构
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
PII-035
引用
收藏
页码:S44 / S45
页数:2
相关论文
共 50 条
  • [41] Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure
    Komazawa, Hiroki
    Yamaguchi, Hiroaki
    Hidaka, Kazuhiro
    Ogura, Jiro
    Kobayashi, Masaki
    Iseki, Ken
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 102 (03) : 1086 - 1094
  • [42] Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity
    Wang, Xue
    Han, Lifeng
    Li, Gentao
    Peng, Wei
    Gao, Xiumei
    Klaassen, Curtis D.
    Fan, Guanwei
    Zhang, Youcai
    TOXICOLOGICAL SCIENCES, 2018, 161 (02) : 321 - 334
  • [43] Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity
    Hu, S.
    Leblanc, A. F.
    Gibson, A. A.
    Hong, K. W.
    Kim, J. Y.
    Janke, L. J.
    Li, L.
    Vasilyeva, A.
    Finkelstein, D. B.
    Sprowl, J. A.
    Sweet, D. H.
    Schlatter, E.
    Ciarimboli, G.
    Schellens, J. H. M.
    Baker, S. D.
    Pabla, N.
    Sparreboom, A.
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2017, 10 (05): : 412 - 420
  • [44] D-Malate decreases renal content of α-ketoglutarate, a driving force of organic anion transporters OAT1 and OAT3, resulting in inhibited tubular secretion of phenolsulfonphthalein, in rats
    Uwai, Yuichi
    Kawasaki, Tatsuya
    Nabekura, Tomohiro
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2017, 38 (08) : 479 - 485
  • [45] Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity
    Hu, Shuiying
    Pabla, Navjotsingh
    Janke, Laura J.
    Li, Lie
    Vasilyeva, Aksana
    Sprowl, Jason A.
    Sparreboom, Alex
    CANCER RESEARCH, 2015, 75
  • [46] Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural
    Bakhiya, Nadiya
    Monien, Bernhard
    Frank, Heinz
    Seidel, Albrecht
    Glatt, Hansruedi
    BIOCHEMICAL PHARMACOLOGY, 2009, 78 (04) : 414 - 419
  • [47] Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3
    Li, Xue
    Qiao, Yilin
    Wang, Xue
    Ma, Ruicong
    Li, Tianxiang
    Zhang, Youcai
    Borris, Robert P.
    JOURNAL OF NATURAL PRODUCTS, 2019, 82 (04): : 832 - 839
  • [48] OAT1, OAT2, OAT3: similarities and discrepancies in transport function
    Burckhardt, B. C.
    Henjakovic, M.
    Hagos, Y.
    Burckhardt, G.
    ACTA PHYSIOLOGICA, 2015, 213 : 83 - 84
  • [49] Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction
    Brandoni, A
    Villar, SR
    Picena, JC
    Anzai, N
    Endou, H
    Torres, AM
    HEPATOLOGY, 2006, 43 (05) : 1092 - 1100
  • [50] OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam
    Wen, Shijie
    Wang, Changyuan
    Duan, Yingjie
    Huo, Xiaokui
    Meng, Qiang
    Liu, Zhihao
    Yang, Shilei
    Zhu, Yanna
    Sun, Huijun
    Ma, Xiaodong
    Yang, Siyun
    Liu, Kexin
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 537 (1-2) : 172 - 182