First trials test targeting of α-synuclein for Parkinson disease

被引：5
|
作者：
Kalia, Lorraine, V [1 ,2 ,3 ,4 ]
机构：
[1] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada
[2] Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada
[3] Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Clin, Toronto, ON, Canada
[4] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada
来源：
NATURE REVIEWS NEUROLOGY | 2022年 / 18卷 / 12期
关键词：
D O I：
10.1038/s41582-022-00726-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In the first two phase II trials of therapies that target alpha-synuclein to treat Parkinson disease, the primary endpoints were not met. However, the limitations of these studies need to be addressed in future trials and alternative approaches to targeting alpha-synuclein should be pursued before alpha-synuclein is discounted as a target.
引用
收藏
页码：703 / 704
页数：2
相关论文
共 50 条
  • [31] α-Synuclein in Parkinson's Disease
    Stefanis, Leonidas
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (02):
  • [32] α-Synuclein and Parkinson's disease
    Burke, RE
    BRAIN RESEARCH BULLETIN, 1999, 50 (5-6) : 465 - 466
  • [33] α-synuclein and Parkinson's disease
    Iwatsubo, T
    SEIKAGAKU, 2002, 74 (06): : 477 - 482
  • [34] α-synuclein and Parkinson's Disease
    Recchia, A
    Debetto, P
    Negro, A
    Guidolin, D
    Skaper, SD
    Giusti, P
    FASEB JOURNAL, 2004, 18 (06): : 617 - 626
  • [35] α-synuclein and Parkinson's disease
    Golbe, LI
    PARKINSON'S DISEASE, 2003, 91 : 165 - 174
  • [36] α-Synuclein and Parkinson disease susceptibility
    Winkler, S.
    Hagenah, J.
    Lincoln, S.
    Heckman, M.
    Haugarvoll, K.
    Lohmann-Hedrich, K.
    Kostic, V.
    Farrer, M.
    Klein, C.
    NEUROLOGY, 2007, 69 (18) : 1745 - 1750
  • [37] β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson's Disease
    Xian, Meiyan
    Li, Jingwen
    Liu, Tingting
    Hou, Kaiying
    Sun, Lin
    Wei, Jianshe
    ACS CHEMICAL NEUROSCIENCE, 2024, 15 (13): : 2445 - 2453
  • [38] Potential for an α-synuclein antibody-based diagnostic test for Parkinson's disease
    不详
    EXPERT REVIEW OF NEUROTHERAPEUTICS, 2011, 11 (06) : 779 - 779
  • [39] Potential for an α-synuclein antibody-based diagnostic test for Parkinson's disease
    不详
    EXPERT REVIEW OF PROTEOMICS, 2011, 8 (03) : 300 - 300
  • [40] Potential for an α-synuclein antibody-based diagnostic test for Parkinson's disease
    不详
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2011, 11 (05) : 470 - 470
12345