Synthesis of 3-aminochroman derivatives by radical cyclization

被引：26

作者：

Pavé, G

Usse-Versluys, S

Viaud-Massuard, MC

Guillaumet, G

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, CNRS, UMR 6005, F-45067 Orleans 2, France

[2] Univ Tours, UFR Sci Pharmaceut, Grp Rech Chimie Heterocyclique & Therapeut, EA 3247, F-37200 Tours, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol0353215

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure 5-acetyl-3-amino-3,4-dihydro-2H-1-benzopyran and methyl 3-amino-3,4-dihydro-2H-1-benzopyran-5-carboxylate were successfully synthesized starting from D- or L-serine. The formation of the benzopyran ring involved a radical cyclization step. The enantiomeric purities of the final aminochroman derivatives were determined by capillary electrophoresis using beta-cyclodextrins as a chiral selector.

引用

页码：4253 / 4256

页数：4

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