Corybungines A-K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity

被引：6

作者：

Han, Yang ^{[1
,2
]}

Hou, Tao ^{[1
]}

Zhang, Zi-Hui ^{[3
]}

Zhu, Yun-Hui ^{[4
]}

Cheng, Jun-Xiang ^{[5
]}

Zhou, Han ^{[1
]}

Wang, Ji-Xia ^{[1
]}

Feng, Jia-Tao ^{[1
]}

Liu, Yan-Fang ^{[1
,4
]}

Guo, Zhi-Mou ^{[1
,4
]}

Liang, Xin-Miao ^{[1
,4
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Dalian Polytech Univ, Sch Biol Engn, Dalian 116034, Peoples R China

[4] Ganjiang Chinese Med Innovat Ctr, Jiangxi Prov Key Lab Pharmacodynam Mat Basis Trad, Nanchang 330000, Jiangxi, Peoples R China

[5] DICP CMC Innovat Inst Med, Taizhou 225300, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 199卷

关键词：

Corydalis bungeana Turcz; Papaveraceae; Corybungines A-K; Isoquinoline alkaloids; D2 antagonistic activity; TRADITIONAL MEDICINAL-PLANTS; THAILAND; TURCZ;

D O I：

10.1016/j.phytochem.2022.113209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eleven undescribed isoquinoline alkaloids corybungines A-K including a protoberberine-type alkaloid, an isoquinoline alkaloid with a unique 6-norprotoberberine skeleton, one 13,14-seco-protoberberine-type alkaloid, two 1a,14-seco-protoberberine-type alkaloids with a 4-(hydroxymethyl)phenoxy moiety and six aporphine alkaloids, together with seven known alkaloids, have been isolated from the whole herb extract of Corydalis bungeana Turcz. Their structures and absolute configurations were elucidated based on an analysis of spectroscopic data and electronic circular dichroism (ECD) spectra. (R)-stephanine displayed high antagonistic activity against the dopamine D2 receptor with an IC50 value of 0.85 +/- 0.09 mu M in CHO-D2 cells. Additionally, corybungines D, F, H, (R)-roemerine, (R)-vireakine and (R)-tuduranine showed moderate D2 antagonism (IC50 5.20-26.07 mu M). The preliminary structure-activity relationships (SARs) of aporphine alkaloids were discussed.

引用

页数：10

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