Synthesis and characterization of new polyamino-cholic acid dimers

被引：0
|
作者：
Shawakfeh, KQ [1 ]
Al-Said, NH [1 ]
Shawish, I [1 ]
机构：
[1] Jordan Univ Sci & Technol, Dept Appl Chem Sci, Irbid 22110, Jordan
来源：
ASIAN JOURNAL OF CHEMISTRY | 2005年 / 17卷 / 01期
关键词：
synthesis; characterization; polyamino-cholic acid; dimers;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cholic acid was selectively protected by trifluoroacetic anhydride, then selectively deprotected at C-3 in order to synthesize 3-keto-diprotected methyl cholate. Dimerization via A-A ring connection was achieved by reductive amination of 3-keto-diprotected methyl cholate with different di and polyamines. Diamines chosen to build SAR were n = 3, 4, 6. In addition, polyarnine (spermidine) was chosen to study the effect of increasing the distance between the two sides of dimer in bioactivity. Several dimeric methyl cholate derivatives were synthesized to evaluate their biological activities.
引用
收藏
页码：91 / 97
页数：7
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