Failure of atovaquone-proguanil malaria chemoprophylaxis in a traveler to Ghana

被引：11
|
作者：
Boggild, Andrea K. [1 ,2 ,3 ]
Lau, Rachel [3 ]
Reynaud, Denis [4 ]
Kain, Kevin C. [1 ,2 ,5 ]
Gerson, Marvin [6 ]
机构：
[1] Univ Hlth Network, Toronto Gen Hosp, Div Infect Dis, Trop Dis Unit, Toronto, ON, Canada
[2] Univ Toronto, Dept Med, Toronto, ON, Canada
[3] Publ Hlth Ontario, Publ Hlth Ontario Labs, Toronto, ON, Canada
[4] Hosp Sick Children, Ctr Study Complex Childhood Dis, Toronto, ON M5G 1X8, Canada
[5] Univ Toronto, Sandra Rotman Ctr Global Hlth, Sandra A Rotman Labs, Toronto, ON M5S 1A1, Canada
[6] Humber River Hosp, N York, ON, Canada
来源：
TRAVEL MEDICINE AND INFECTIOUS DISEASE | 2015年 / 13卷 / 01期
关键词：
Drug resistance; Malabsorption; Malaria; Malarone; Plasmodium falciparum; TIME QUANTITATIVE PCR; GENE COPY NUMBER; PLASMODIUM-FALCIPARUM; GEOSENTINEL SURVEILLANCE; RETURNED TRAVELERS; TREATMENT POLICY; RESISTANCE; CHLOROQUINE; CHILDREN; DISEASES;
D O I：
10.1016/j.tmaid.2014.12.010
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Clinical failure of Malarone (TM) chemoprophylaxis is extremely rare. We report a case of Plasmodium falciparum malaria in a returned traveler to Ghana who fully adhered to atovaquone-proguanil (Malarone (TM)) chemoprophylaxis daily dosing, yet took the pills on an empty stomach. Screening of the P. falciparum isolate revealed triple codon mutation of Dhfr at positions 51, 59, and 108. Plasma drug levels of both atovaquone and proguanil revealed sub-therapeutic concentrations. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：89 / 93
页数：5
相关论文
共 50 条
  • [41] Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmosium falciparum malaria in Thailand
    Krudsood, Srivicha
    Patel, Samir N.
    Tangpukdee, Nopaddon
    Thanachartwet, Wipa
    Leowattana, Wattana
    Pornpininworakij, Karnchana
    Boggild, Andrea K.
    Looareesuwan, Sornchai
    Kain, Kevin C.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 76 (04): : 655 - 658
  • [42] Atovaquone-proguanil (Malarone):: an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark
    Thybo, SR
    Gjorup, I
    Ronn, AM
    Meyrowitsch, D
    Bygberg, IC
    JOURNAL OF TRAVEL MEDICINE, 2004, 11 (04) : 220 - 224
  • [43] Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis
    Jimenez, Beatriz C.
    Navarro, Miriam
    Huerga, Helena
    Lopez-Roman, Eva
    Mendoza, Alfonso
    Lopez-Vélez, Rogelio
    JOURNAL OF TRAVEL MEDICINE, 2006, 13 (06) : 373 - 375
  • [44] Delayed Onset of Symptoms and Atovaquone-Proguanil Chemoprophylaxis Breakthrough by Plasmodium malariae in the Absence of Mutation at Codon 268 of pmcytb
    Teo, Beatrix Huei-Yi
    Lansdell, Paul
    Smith, Valerie
    Blaze, Marie
    Nolder, Debbie
    Beshir, Khalid B.
    Chiodini, Peter L.
    Cao, Jun
    Farnert, Anna
    Sutherland, Colin J.
    PLOS NEGLECTED TROPICAL DISEASES, 2015, 9 (10):
  • [45] Lengthy antimalarial activity of atovaquone in human plasma following atovaquone-proguanil administration
    Edstein, MD
    Kotecka, BM
    Anderson, KL
    Pombo, DJ
    Kyle, DE
    Rieckmann, KH
    Good, MF
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (10) : 4421 - 4422
  • [46] Atovaquone-proguanil treatment failure in a case of pediatric Plasmodium falciparum infection: Malabsorption and resistance
    L'Huillier, Arnaud G.
    Lau, Rachel
    Bitnun, Ari
    Boggild, Andrea K.
    TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2020, 37
  • [47] Imported malaria management in France -: Experience report of uncomplicated falciparum malaria treatment in adults with oral atovaquone-proguanil
    Vatan, R
    Pistone, T
    Millet, P
    Etienne, G
    Mercié, P
    Longy-Boursier, M
    Malvy, D
    PRESSE MEDICALE, 2006, 35 (04): : 571 - 577
  • [48] A survey on outcomes of accidental atovaquone-proguanil exposure in pregnancy
    Tan, Kathrine R.
    Fairley, Jessica K.
    Wang, Mengxi
    Gutman, Julie R.
    MALARIA JOURNAL, 2018, 17
  • [49] Artemether-Lumefantrine Compared to Atovaquone-Proguanil as a Treatment for Uncomplicated Plasmodium falciparum Malaria in Travelers
    Grynberg, Shiny
    Lachish, Tamar
    Kopel, Eran
    Meltzer, Eyal
    Schwartz, Eli
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 92 (01): : 13 - 17
  • [50] Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment
    Forestier, E.
    Labe, A.
    Raffenot, D.
    Lecomte, C.
    Rogeaux, O.
    MEDECINE ET MALADIES INFECTIEUSES, 2011, 41 (01): : 41 - 43
12345