Failure of atovaquone-proguanil malaria chemoprophylaxis in a traveler to Ghana

被引：11
|
作者：
Boggild, Andrea K. [1 ,2 ,3 ]
Lau, Rachel [3 ]
Reynaud, Denis [4 ]
Kain, Kevin C. [1 ,2 ,5 ]
Gerson, Marvin [6 ]
机构：
[1] Univ Hlth Network, Toronto Gen Hosp, Div Infect Dis, Trop Dis Unit, Toronto, ON, Canada
[2] Univ Toronto, Dept Med, Toronto, ON, Canada
[3] Publ Hlth Ontario, Publ Hlth Ontario Labs, Toronto, ON, Canada
[4] Hosp Sick Children, Ctr Study Complex Childhood Dis, Toronto, ON M5G 1X8, Canada
[5] Univ Toronto, Sandra Rotman Ctr Global Hlth, Sandra A Rotman Labs, Toronto, ON M5S 1A1, Canada
[6] Humber River Hosp, N York, ON, Canada
来源：
TRAVEL MEDICINE AND INFECTIOUS DISEASE | 2015年 / 13卷 / 01期
关键词：
Drug resistance; Malabsorption; Malaria; Malarone; Plasmodium falciparum; TIME QUANTITATIVE PCR; GENE COPY NUMBER; PLASMODIUM-FALCIPARUM; GEOSENTINEL SURVEILLANCE; RETURNED TRAVELERS; TREATMENT POLICY; RESISTANCE; CHLOROQUINE; CHILDREN; DISEASES;
D O I：
10.1016/j.tmaid.2014.12.010
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Clinical failure of Malarone (TM) chemoprophylaxis is extremely rare. We report a case of Plasmodium falciparum malaria in a returned traveler to Ghana who fully adhered to atovaquone-proguanil (Malarone (TM)) chemoprophylaxis daily dosing, yet took the pills on an empty stomach. Screening of the P. falciparum isolate revealed triple codon mutation of Dhfr at positions 51, 59, and 108. Plasma drug levels of both atovaquone and proguanil revealed sub-therapeutic concentrations. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：89 / 93
页数：5
相关论文
共 50 条
  • [1] Malaria Chemoprophylaxis With Atovaquone-Proguanil: Is a Shorter Regimen Fully Protective?
    Grobusch, Martin P.
    JOURNAL OF TRAVEL MEDICINE, 2014, 21 (02) : 79 - 81
  • [2] Atovaquone-proguanil chemoprophylaxis in the era of Tafenoquine
    Meltzer, Eyal
    Schwartz, Eli
    JOURNAL OF TRAVEL MEDICINE, 2019, 26 (04)
  • [3] Plasmodium falciparum malaria and atovaquone-proguanil treatment failure
    Durand, Remy
    Prendki, Virginie
    Cailhol, Johann
    Hubert, Vronique
    Ralaimazava, Pascal
    Massias, Laurent
    Bouchaud, Olivier
    Le Brast, Jacques
    EMERGING INFECTIOUS DISEASES, 2008, 14 (02) : 320 - 322
  • [4] Vivax Malaria Chemoprophylaxis: The Role of Atovaquone-Proguanil Compared to Other Options
    Meltzer, Eyal
    Rahav, Galia
    Schwartz, Eli
    CLINICAL INFECTIOUS DISEASES, 2018, 66 (11) : 1751 - 1755
  • [5] Failure of atovaquone-proguanil chemoprophylaxis and chloroquine treatment in Plasmodium malariae infection
    Visser, Roos
    de Mast, Quirijn
    Munnix, Imke
    van der Ven, Andre
    Dofferhoff, Ton
    TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2016, 14 (06) : 644 - 645
  • [6] Atovaquone-proguanil: Report from the CDC expert meeting on malaria chemoprophylaxis (II)
    Boggild, Andrea K.
    Parise, Monica E.
    Lewis, Linda S.
    Kain, Kevin C.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 76 (02): : 208 - 223
  • [7] Atovaquone-proguanil for prophylaxis and treatment of malaria
    Marra, F
    Salzman, JR
    Ensom, MHH
    ANNALS OF PHARMACOTHERAPY, 2003, 37 (09) : 1266 - 1275
  • [8] Atovaquone-proguanil for treating uncomplicated malaria
    Osei-Akoto, A.
    Orton, L.
    Owusu-Ofori, S. P. O.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2005, (04):
  • [9] Atovaquone-proguanil for falciparum malaria in the Philippines
    Watt, G
    JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01): : 405 - 405
  • [10] Fluindione and falciparum malaria treated by atovaquone-proguanil
    Kamaliddin, Claire
    Joste, Valentin
    Argy, Nicolas
    Houze, Sandrine
    THERAPIE, 2018, 73 (05): : 445 - 447
12345