Quantitative analysis of aquaporin-4 antibody in longitudinally extensive transverse myelitis

被引：8

作者：

Wang, Jing ^{[1
]}

Li, Xin ^{[1
]}

Zhang, Da-Qi ^{[1
]}

Yang, Chun-Sheng ^{[1
]}

Qi, Yuan ^{[1
]}

Li, Min-Shu ^{[1
]}

Shi, Fu-Dong ^{[1
,2
]}

Yang, Li ^{[1
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China

[2] St Josephs Hosp, Barrow Neurol Inst, Dept Neurol, Phoenix, AZ USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 278卷

基金：

中国国家自然科学基金;

关键词：

Longitudinally extensive transverse myelitis; Neuromyelitis optics spectrum disorders; Aquaporin-4; antibody; Fluorescence immunoprecipitation assay; Clinical features; NEUROMYELITIS-OPTICA; CLINICAL-FEATURES; NMO; IMMUNOPATHOGENESIS; DIAGNOSIS; MARKER;

D O I：

10.1016/j.jneuroim.2014.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aquaporin-4 (AQP-4) antibody-positive longitudinally extensive transverse myelitis (LETM) is referred to as a neuromyelitis optica (NMO) spectrum disorder. We conducted an exploratory investigation of correlations between AQP-4 antibody serum levels, as determined by a fluorescent immunoprecipitation assay, and clinical characteristics in LETM. Expanded Disability Status Scores (EDSS) scores and number of segments of spinal cord involved were positively correlated to AQP-4 antibody levels. However, serum AQP-4 antibody levels were not correlated with the time to next attack or the conversion time of LETM to NMO, although seropositive LETM patients demonstrated a high conversion rate to NMO (78.1%). (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：26 / 29

页数：4

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