Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population

被引：8

作者：

Sanchez, Monica Siqueiros ^{[1
,2
]}

Pettersson, Erik ^{[3
]}

Kennedy, Daniel P. ^{[4
]}

Bolte, Sven ^{[1
,2
,5
]}

Lichtenstein, Paul ^{[3
]}

D'Onofrio, Brian M. ^{[3
,4
]}

Falck-Ytter, Terje ^{[1
,2
,6
,7
]}

机构：

[1] Karolinska Inst, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, Div Neuropsychiat, S-11330 Stockholm, Sweden

[2] Stockholm Cty Council, Ctr Psychiat Res, S-11364 Stockholm, Sweden

[3] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17165 Stockholm, Sweden

[4] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[5] Stockholm Cty Council, Child & Adolescent Psychiat, S-11330 Stockholm, Sweden

[6] Uppsala Univ, Dept Psychol, S-75142 Uppsala, Sweden

[7] Swedish Coll Adv Study SCAS, S-75238 Uppsala, Sweden

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2020年 / 50卷 / 06期

基金：

瑞典研究理事会;

关键词：

Visual disengagement; Gap-overlap task; Behavior genetics; Autistic traits; Autism spectrum disorders; UNIMPAIRED ATTENTIONAL DISENGAGEMENT; SACCADIC EYE-MOVEMENTS; SPECTRUM DISORDERS; IMPAIRED DISENGAGEMENT; YOUNG-CHILDREN; REACTION-TIMES; GAP; RISK; OVERLAP; INDEPENDENCE;

D O I：

10.1007/s10803-019-03974-6

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Visual disengagement has been hypothesized as an endophenotype for autism. In this study we used twin modelling to assess the role of genetics in basic measures of visual disengagement, and tested their putative association to autistic traits in the general population. We used the Gap Overlap task in a sample of 492 twins. Results showed that most of the covariance among eye movement latencies across conditions was shared and primarily genetic. Further, there were unique genetic contributions to the Gap condition, but not to the Overlap condition-i.e. the one theorized to capture visual disengagement. We found no phenotypic association between autistic traits and disengagement, thus not supporting the hypothesis of visual disengagement as an endophenotype for autistic traits.

引用

页码：2188 / 2200

页数：13

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