Radiofrequency catheter ablation of premature ventricular contractions originating in the right ventricular outflow tract

Objectives: To evaluate if radiofrequency catheter ablation is an effective procedure for the treatment of right ventricular outflow tract premature ventricular contractions (RVOT-PVC) and ascertain if it results in an improvement of symptoms. Methods: A prospective study with 30 consecutive. patients (mean age 40 +/- 13 years, 25 females), with no apparent structural cardiopathy, with very frequent (mean density of 1,263 +/- 593/h) RVOT-PVC, symptomatic for more than one year (mean = 74 months) and resistant to antiarrhythmic drugs (3 +/- 1.7, including beta-blockers), who underwent radiofrequency catheter ablation. Results: After the first procedure, there were 23 initial successful cases (76.6%) and 7 initial failures (23.4%). Four patients experienced relapses, two of whom did not undergo the second procedure. The second procedure was carried out in 9 patients (7 initial failures and 2 relapses), and there was success in 5 additional patients, one of them by epicardial access. The final success rate was 80% (24130), and there were no major complications. After a mean follow-up of 14 6 months, in the successful group there was a reduction greater than 90% in density of premature ventricular contractions (PVC) (24/24; p <0.0001) and a resulting absence of symptoms in the majority of patients (23124; p < 0.001). Conclusion. Radiofrequency catheter ablation is a safe and effective treatment for patients with persistent. and symptomatic PVC with RVOT morphology.