Necrotizing toxoplasmic encephalitis in a child with the X-linked hyper-IgM syndrome

被引：19

作者：

Tsuge, I ^{[1
]}

Matsuoka, H ^{[1
]}

Nakagawa, A ^{[1
]}

Kamachi, Y ^{[1
]}

Aso, K ^{[1
]}

Negoro, T ^{[1
]}

Ito, M ^{[1
]}

Torii, S ^{[1
]}

Watanabe, K ^{[1
]}

机构：

[1] Nagoya Univ Hosp, Dept Pathol, Nagoya, Aichi 466, Japan

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1998年 / 157卷 / 09期

关键词：

hyper-IgM syndrome; CD40; ligand; necrotizing toxoplasmic encephalitis;

D O I：

10.1007/s004310050925

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report on a 9-year-old boy with the hyper-IgM syndrome who presented with rapid impairment of consciousness. The brain CT scan showed multiple round lucencies, and the brain histology revealed necrotizing toxoplasmic encephalitis. This patient, whose CD40/CD40 ligand system was impaired, indicates the importance of this system for defence against toxoplasmic infection. Conclusion Although disseminated toxoplasmosis is a rare complication of the hyper-IgM syndrome, it must be included in the differential diagnosis of infections.

引用

页码：735 / 737

页数：3

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