Enhanced level and durability of AAV transgene expression and mitigation of anti-capsid neutralizing antibodies by ImmTOR tolerogenic nanoparticles in nonhuman primates

被引：0

作者：

Kishimoto, T. K. ^{[1
]}

Elkins, S. ^{[1
]}

Capela, T. ^{[1
]}

Rizzo, G. ^{[1
]}

Ilyinskii, P. O. ^{[1
]}

Leung, S. S. ^{[1
]}

机构：

[1] Selecta Biosci, Watertown, MA USA

来源：

HUMAN GENE THERAPY | 2021年 / 32卷 / 19-20期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

P003

引用

页码：A28 / A29

页数：2

共 23 条

[21] Global CNS Gene Delivery in Non-Human Primates by Intra-CSF Administration: Evasion of Anti-AAV Neutralizing Antibodies but Not a Transgene-Specific CTL Response
Gray, Steven J.
Kalburgi, Sahana Nagabhushan
McCown, Thomas J.
Samulski, R. Jude
MOLECULAR THERAPY, 2013, 21 : S46 - S46
[22] ImmTOR tolerogenic nanoparticles combined with Treg-selective IL-2 mutein induces massive expansion of antigen-specific regulatory T cells and synergistically inhibit formation of anti-AAV antibodies to high vector doses
Kishimoto, T. K.
Michaud, A. M.
Rizzo, G. L.
Roy, C. J.
Fournier, M.
Capella, T.
Leung, S. S.
Ilyinskii, P. O.
HUMAN GENE THERAPY, 2022, 33 (23-24) : A4 - A4
[23] First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies
Pipe, Steven W.
Recht, Michael
Key, Nigel S.
Leebeek, Frank W. G.
Castaman, Giancarlo
Lattimore, Susan U.
Van der Valk, Paul
Peerlinck, Kathelijne
Coppens, Michiel
O'Connell, Niamh
Pasi, John
Kampmann, Peter
Meijer, Karina
Von Drygalski, Annette
Young, Guy
Hermans, Cedric
Astermark, Jan
Klamroth, Robert
Lemons, Richard S.
Visweshwar, Nathan
Crary, Shelley
Kazmi, Rashid
Symington, Emily
Escobar, Miguel A.
Gomez, Esteban
Kruse-Jarres, Rebecca
Kotowski, Adam
Quon, Doris
Wang, Michael
Wheeler, Allison P.
Sawyer, Eileen K.
Verweij, Stephanie
Colletta, Valerie
Bajma, Naghmana
Gut, Robert
Miesbach, Wolfgang A.
BLOOD, 2020, 136

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