Altered cortical excitability in patients with untreated obstructive sleep apnea syndrome

被引:22
|
作者
Joo, Eun Yeon [1 ]
Kim, Hye-Jung [1 ]
Lim, Yang-Hee [1 ]
Koo, Dae-Lim [1 ]
Hong, Seung Bong [1 ]
机构
[1] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med,Sleep Ctr, Seoul 135710, South Korea
关键词
Obstructive sleep apnea syndrome; Transcranial magnetic stimulation; Cortical excitability; Resting motor threshold; Cortical silent period; Motor evoked potential; HUMAN MOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; CORTICOCORTICAL INHIBITION; PULMONARY-DISEASE; DECREASES; ABNORMALITIES; DEPRIVATION; WAKEFULNESS; EPILEPSY; DEFICITS;
D O I
10.1016/j.sleep.2010.02.015
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To investigate cortical excitability in patients with obstructive sleep apnea syndrome (OSAS) during wakefulness. Methods: The authors recruited 45 untreated severe OSAS (all males, mean age 47.2 years, mean apnea-hypopnea index = 44.6 h(-1)) patients and 44 age-matched healthy male volunteers (mean apnea-hypopnea index = 3.4 h(-1)). The TMS parameters measured were resting motor threshold (RMT), motor evoked potential (MEP) amplitude, cortical silent period (CSP), and short-interval intracortical inhibition (SIC!) and intracortical facilitation (ICE). These parameters were measured in the morning (9-10 am) more than 2 h after arising and the parameters of patients and controls were compared. The Epworth Sleepiness Scale (ESS) and the Stanford Sleepiness Scale (SSS) were also measured before the TMS study. Results: OSAS patients had a significantly higher RMT and a longer CSP duration (t-test, p < 0.001) compared to healthy volunteers. No significant difference was observed between MEP amplitudes at any stimulus intensity or between the SIC! (2, 3, 5 ms) and ICF (10, 15, 20 ms) values of OSAS patients and healthy volunteers (p > 0.05). Conclusions: This TMS-based study suggests that untreated severe OSAS patients have imbalanced cortical excitabilities that enhanced inhibition or decreased brain excitability when awake during the day. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:857 / 861
页数:5
相关论文
共 50 条
  • [21] Enuresis in obstructive sleep apnea syndrome patients
    Lykouras, Dimosthenis
    Sargianou, Maria
    Karkoulias, Kiriakos
    Sampsonas, Fotios
    Theodoropoulos, Kleanthis
    Skoura, Angeliki
    Voulgaridis, Apostolos
    Spiropoulos, Kostas
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [22] Dentition in Obstructive Sleep Apnea Syndrome Patients
    Korczynski, P.
    Gorska, K.
    Bielicki, P.
    Chazan, R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [23] Obstructive sleep apnea syndrome patients and hypozincemia
    Chikaya Hattori
    Kenji Suzuki
    Kenji Kawakatsu
    Arata Yonekura
    Tadao Nishimura
    Sleep and Biological Rhythms, 2005, 3 (1) : 45 - 46
  • [24] Rehabilitation of patients with obstructive sleep apnea syndrome
    Chwiesko-Minarowska, Sylwia
    Minarowski, Lukasz
    Kuryliszyn-Moskal, Anna
    Chwiesko, Jan
    Chyczewska, Elzbieta
    INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH, 2013, 36 (04) : 291 - 297
  • [25] OBSTRUCTIVE SLEEP APNEA SYNDROME IN GERIATRIC PATIENTS
    Levent, Ender
    Sariman, Nesrin
    TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI, 2012, 15 (02): : 179 - 187
  • [26] Frequency of COPD and Asthma in Patients with Obstructive Sleep Apnea Syndrome and Their Effects on Severity of Obstructive Sleep Apnea Syndrome and Quality of Sleep
    Salepci, Banu Musaffa
    Fidan, Ali
    Kiral, Nesrin
    Parmaksiz, Elif Torun
    Sarac, Gulsen
    Comert, Sevda Sener
    Caglayan, Benan
    EURASIAN JOURNAL OF PULMONOLOGY, 2012, 14 (03) : 141 - 147
  • [27] Altered Cortical Information Interaction During Respiratory Events in Children with Obstructive Sleep Apnea-Hypopnea Syndrome
    Chen, Jin
    Lin, Minmin
    Shi, Naikai
    Shen, Jingxian
    Weng, Xuchu
    Pang, Feng
    Liang, Jiuxing
    NEUROSCIENCE BULLETIN, 2024, 40 (10) : 1458 - 1470
  • [28] ALTERED BRAIN NETWORK ORGANIZATION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
    Park, H.
    Cha, J.
    Kim, H.
    Joo, E.
    SLEEP, 2020, 43 : A275 - A276
  • [29] Sex Differences in Central Hemodynamics of Patients with Untreated Obstructive Sleep Apnea
    Bock, Joshua
    Allgauer, Chieko
    Vungarala, Soumya
    Singh, Prachi
    Somers, Virend
    PHYSIOLOGY, 2024, 39
  • [30] Thalamic altered spontaneous activity and connectivity in obstructive sleep apnea syndrome
    Santarnecchi, Emiliano
    Sprugnoli, Giulia
    Sicilia, Isabella
    Dukart, Juergen
    Neri, Francesco
    Romanella, Sara M.
    Cerase, Alfonso
    Vatti, Giampaolo
    Rocchi, Raffaele
    Rossi, Alessandro
    JOURNAL OF NEUROIMAGING, 2022, 32 (02) : 314 - 327