A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans

被引：5

作者：

Bentz, Eva-Katrin

Hefler, Lukas A.

Denschlag, Dominik

Pietrowski, Detlef

Buerkle, Bernd

Tempfer, Clemens B.

机构：

[1] Univ Vienna, Sch Med, Dept Obstet & Gynecol, A-1090 Vienna, Austria

[2] Univ Vienna, Sch Med, Dept Gynecol Endocrinol, Vienna, Austria

[3] Univ Vienna, Sch Med, Dept Reprod Med, Vienna, Austria

[4] Univ Freiburg, Dept Gynecol & Obstet, D-7800 Freiburg, Germany

来源：

FERTILITY AND STERILITY | 2007年 / 88卷 / 03期

关键词：

D O I：

10.1016/j.fertnstert.2006.11.174

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

a prospective case-control study of 127 normozoospermic and 435 non-normozoospermic Caucasian men, the genotype frequencies of a polymorphism of the interleukin-1 beta gene (IL-1 beta Taq C-->T) were statistically significantly different between groups (homozygous wild-type C/C [57%], heterozygous C/T [42%], and homozygous mutant T/T [1%] vs. C/C [57%], C/T [36%], T/T [7%] for normozoospermic and non-normozoospermic men, respectively; odds ratio, 4.8; 95% confidence interval, 1.13 to 20.28). This association was restricted to men with the oligoasthenoteratozoospermia (OAT) syndrome. We conclude that the investigated polymorphism is associated with sperm pathology in Caucasians.

引用

页码：751 / 753

页数：3

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