Evidence-based Dental Care: Perspective on Levels of Evidence

The objective of this review was to consider compilation of evidence from literature and its interpretation. Evidence-based dentistry during its implementation has sometimes emphasized randomized clinical trials with exclusion of all other evidence. Systematic reviews must compile evidence from all study types, with the collected evidence processed through the Grading of Recommendations Assessment, Development and Evaluation system prior to their application in clinical decision-making. Evidence-based clinical practice should be based upon transparently reported evidence from all study types.