Natural regulatory T cells in autoimmunity

被引：97
|
作者：
Lourenco, Elaine V. [1 ]
La Cava, Antonio [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
来源：
AUTOIMMUNITY | 2011年 / 44卷 / 01期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
Tregs; CD4(+)CD25(+)FOXP3(+) T cells; natural Tregs; autoimmunity; GROWTH-FACTOR-BETA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOLOGICAL SELF-TOLERANCE; DENDRITIC CELLS; TGF-BETA; CUTTING EDGE; SUPPRESSOR FUNCTION; HELPER TYPE-1; FUNCTIONAL-CHARACTERIZATION; INTERLEUKIN-10; PRODUCTION;
D O I：
10.3109/08916931003782155
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.
引用
收藏
页码：33 / 42
页数：10
相关论文
共 50 条
  • [21] Regulatory T cells in the control of transplantation tolerance and autoimmunity
    Jiang, SP
    Lechler, RI
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2003, 3 (05) : 516 - 524
  • [22] T regulatory cells between autoimmunity and tumour immunity
    Fattorossi, Andrea
    [J]. CYTOMETRY PART A, 2008, 73A (01) : 56 - 57
  • [23] MicroRNA signature of regulatory T cells in health and autoimmunity
    Soltanzadeh-Yamchi, Mehdi
    Shahbazi, Mehdi
    Aslani, Saeed
    Mohammadnia-Afrouzi, Mousa
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2018, 100 : 316 - 323
  • [24] Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle
    Hatzioannou, Aikaterini
    Boumpas, Athina
    Papadopoulou, Miranta
    Papafragkos, Iosif
    Varveri, Athina
    Alissafi, Themis
    Verginis, Panayotis
    [J]. FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [25] Regulatory T cells: Development, function and role in autoimmunity
    Lan, RY
    Ansari, AA
    Lian, ZX
    Gershwin, ME
    [J]. AUTOIMMUNITY REVIEWS, 2005, 4 (06) : 351 - 363
  • [26] Regulatory T Cells: Key Players in Tolerance and Autoimmunity
    Chatila, Talal A.
    [J]. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2009, 38 (02) : 265 - +
  • [27] Antigen-induced regulatory T cells in autoimmunity
    Matthias G. von Herrath
    Leonard C. Harrison
    [J]. Nature Reviews Immunology, 2003, 3 : 223 - 232
  • [28] Therapeutic modulation of cutaneous autoimmunity by regulatory T cells
    Loser, K.
    Beissert, S.
    [J]. RHEUMATOLOGY, 2006, 45 : 20 - 22
  • [29] Natural killer T cells: natural or unnatural regulators of autoimmunity?
    Hammond, KJL
    Kronenberg, M
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (06) : 683 - 689
  • [30] Anti-regulatory T cells are natural regulatory effector T cells
    Odum, Niels
    [J]. CELL STRESS, 2019, 3 (10) : 310 - 311
12345