Efficacy of Submucosal Injection of Chymotrypsin, Oral Serratiopeptidase or Oral Dexamethasone in Reducing Postoperative Complications Following Impacted Lower Third Molar Surgery: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial

被引:2
|
作者
Al-Moraissi, Essam Ahmed [1 ]
Al-Zendani, Elham Aziz [2 ]
Al-Selwi, Abeer Mohammed [2 ]
机构
[1] Thamar Univ, Dept Oral & Maxillofacial Surg, Dhamar, Yemen
[2] Univ Sci & Technol, Sanaa, Yemen
来源
关键词
chymotrypsin; oral serratiopeptidase; postoperative complications; dexamethasone; lower third molars surgery; SURGICAL EXTRACTION; PAIN; TRISMUS; CORTICOSTEROIDS; BROMELAIN;
D O I
10.3389/froh.2020.575176
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Aim The study aimed to compare between chymotrypsin, oral serratiopeptidase, and oral dexamethasone following impacted mandibular third molars surgery in respect of postoperative complications.Materials and method: A randomized, double-blind clinical trial was conducted on 60 patients who were candidates for impacted mandibular third molars surgery and randomly allocated into the following 3 groups: submucosal chymotrypsin (5 mg), oral serratiopeptidase (10 mg), and oral dexamethasone (8 mg) (each group = 20). The outcome variables were postoperative pain (via visual analog scale), facial swelling (via tape method) and maximal mouth opening immediately after 2nd, 3rd, and 5th postoperative days.Results: A total of 60 patients underwent randomization and allocation concealment and were included in the current study. All of the subjects tolerated the medicines with no untoward side or adverse effects. There was no statistically significant difference between the three groups in respect of postoperative pain intensity, facial swelling and maximal mouth opening at the immediate first hour, 2nd, 3rd, and 5th postoperative days (P < 0.05).Conclusion: The present randomized clinical trial concluded that preemptive sub-mucosal injection of chymotrypsin yields a comparable effectiveness in decreasing postoperative sequelae following impacted mandibular third molars surgery when compared to oral serratiopeptidase or dexamethasone. This is the first Randomized Clinical Trail that assessed efficacy and safety of sub-mucosal injection of chymotrypsin after impacted mandibular third molars surgery. This trial is registered at clinicaltrials.in.th, number (TCTR20200828006).
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Double-blind, randomized controlled clinical trial on analgesic efficacy of local anesthetics articaine and bupivacaine after impacted third molar extraction
    Maria Victoria Olmedo-Gaya
    Francisco Javier Manzano-Moreno
    Jose Luis Muñoz-López
    Manuel Francisco Vallecillo-Capilla
    Candela Reyes-Botella
    Clinical Oral Investigations, 2018, 22 : 2981 - 2988
  • [22] Comparison of the analgesic efficacy of oral ketorolac versus intramuscular tramadol after third molar surgery: A parallel, double-blind, randomized, placebo-controlled clinical trial
    Isiordia-Espinoza, Mario-Alberto
    Pozos-Guillen, Amaury
    Martinez-Rider, Ricardo
    Perez-Urizar, Jose
    MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, 2016, 21 (05): : E637 - E643
  • [23] The AAHKS Clinical Research Award: Oral Dexamethasone Following Total Knee Arthroplasty: A Double-Blind, Randomized Controlled Trial
    Shaw, Jonathan H.
    Wesemann, Luke D.
    Banka, Trevor R.
    North, Wayne T.
    Charters, Michael A.
    Davis, Jason J.
    JOURNAL OF ARTHROPLASTY, 2023, 38 (07): : S15 - S20
  • [24] Comparison of Efficacy of Combination of Bromelain, Rutocide, and Trypsin With Serratiopeptidase on Postoperative Sequelae Following Mandibular Third Molar Surgery: A Randomized Clinical Trial
    Chandra, Raparthi Bhuvan
    Selvarasu, Kathiravan
    Krishnan, Murugesan
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (11)
  • [25] Efficacy of postoperative oral metronidazole for haemorrhoidectomy pain: a randomized double-blind, placebo-controlled trial
    Wilkie, B. D.
    Chandra, R.
    Chua, J.
    Lam, D. C. S.
    Paratz, E. D.
    An, V
    Keck, J. O.
    COLORECTAL DISEASE, 2021, 23 (01) : 274 - 282
  • [26] Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: A randomized clinical trial
    Esparza-Villalpando, Vicente
    Chavarria-Bolanos, Daniel
    Gordillo-Moscoso, Antonio
    Masuoka-Ito, David
    Martinez-Rider, Ricardo
    Isiordia-Espinoza, Mario
    Pozos-Guillen, Amaury
    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 2016, 44 (09) : 1350 - 1355
  • [27] Effect of Photobiomodulation on the Incidence of Alveolar Osteitis and Postoperative Pain following Mandibular Third Molar Surgery: A Double-Blind Randomized Clinical Trial
    Nejat, Amir Hossein
    Eshghpour, Majid
    Danaeifar, Nasrin
    Abrishami, Majid
    Vahdatinia, Farshid
    Fekrazad, Reza
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2021, 97 (05) : 1129 - 1135
  • [28] AND LOCAL KETAMINE IMPROVE POSTOPERATIVE ANALGESIA FOLLOWING THIRD MOLAR SURGERY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL STUDY
    Topan, Cihan
    Karakaya, Mustafa
    Demirbas, Ahmet Emin
    Bilge, Suheyb
    Canpolat, Dilek Gunay
    JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE, 2024, 24 (01)
  • [29] Oral dexamethasone decreases postoperative pain, swelling, and trismus more than diclofenac following third molar removal: a randomized controlled clinical trial
    Lima C.A.A.
    Favarini V.T.
    Torres A.M.
    da Silva R.A.
    Sato F.R.L.
    Oral and Maxillofacial Surgery, 2017, 21 (3) : 321 - 326
  • [30] Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction: a randomized, double-blind clinical trial
    Marques, Rogerio Vera Cruz Ferro
    Branco-de-Almeida, Luciana Salles
    Marques, Daniele Meira Conde
    de Oliveira, Izabel Cristina Vieira
    Mendes, Saulo Jose Figueiredo
    Rodrigues, Vandilson Pinheiro
    Lopes, Fernanda Ferreira
    MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, 2022, 27 (01): : E51 - E58