The regulatory role of eosinophils in viral, bacterial, and fungal infections

被引：15

作者：

Gaur, Pratibha ^{[1
]}

Zaffran, Ilan ^{[1
]}

George, Tresa ^{[1
]}

Alekberli, Fidan Rahimli ^{[1
]}

Ben-Zimra, Micha ^{[1
]}

Levi-Schaffer, Francesca ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Inst Drug Res, Pharmacol & Expt Therapeut Unit,Sch Pharm, Jerusalem, Israel

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2022年 / 209卷 / 01期

基金：

以色列科学基金会;

关键词：

eosinophils; bacteria; virus; fungus; infections; FC-EPSILON-RI; STAPHYLOCOCCUS-AUREUS; BIOLOGICAL-PROPERTIES; MURINE EOSINOPHILS; BLOOD EOSINOPHILS; CANDIDA-ALBICANS; IMMUNOGLOBULIN-A; GM-CSF; IGA; RECEPTORS;

D O I：

10.1093/cei/uxac038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review summarizes some of the updated information/recent findings on the role of eosinophil direct and antibody mediated interactions with pathogens. Eosinophils are innate immune cells typically associated with allergic and parasitic diseases. However, in recent years, eosinophils have also been ascribed a role in keeping homeostasis and in fighting several infectious diseases. Indeed, these cells circulate as mature cells in the blood and can be quickly recruited to the infected tissue. Moreover, eosinophils have all the necessary cellular equipment such as pattern recognition receptors (PRRs), pro-inflammatory cytokines, anti-bacterial proteins, and DNA traps to fight pathogens and promote an efficient immune response. This review summarizes some of the updated information on the role of eosinophils' direct and indirect mediated interactions with pathogens.

引用

页码：72 / 82

页数：11

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